Pratik Sinha1, Carolyn S Calfee2. 1. Division of Clinical and Translational Research and Division of Critical Care, Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: p.sinha@wustl.edu. 2. Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.