Long-Ying Deng1, Xiang-Fu Zeng1, Dan Tang2, Wei Deng1, Hong-Fu Liu1, Yuan-Kang Xie3. 1. Department of Gastrointestinal Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. 2. Department of General Practice, First Affiliated Hospital of Nanchang University, Nanchang, China. 3. Department of Hepatobiliary Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Abstract
BACKGROUND: Thrombospondins (THBSs) are glycoproteins expressed in the extracellular matrix (ECM) and have critical roles in tumor development and metastasis. However, the diverse expression patterns and prognostic roles of distinct THBS genes in gastric cancer have not been fully elucidated. In the current study, we aimed to investigate the expression patterns of THBSs in gastric cancer (GC) and determine whether they are prognostic markers for this malignancy. METHODS: mRNA expression status and genetic mutations of THBS family members were performed by using ONCOMINE, UCSC Xena browser, GEPIA, and cBioPortal databases. Prognostic values and function enrichment analysis of the members were assessed via Kaplan-Meier plotter and Metascape. RESULTS: we found that the mRNA expression of THBS1, THBS2, THBS4, and COMP were higher in patients with GC tissues than those in normal gastric mucosa and there was no difference in the mRNA expression of THBS3 between GC and normal tissue. Survival analysis revealed that mRNA levels of THBSs were strongly related to worse OS in GC patients (P<0.05). Overexpression of THBSs indicated poor OS in stage III/IV GC and high expression of THBS1, THBS3, THBS4, and COMP were related to worse OS in stage II GC. CONCLUSIONS: Bioinformatics analysis revealed a better understanding the value of THBS family members in GC and suggest that THBSs might serve as potential prognostic biomarkers for GC. 2021 Journal of Gastrointestinal Oncology. All rights reserved.
BACKGROUND: Thrombospondins (THBSs) are glycoproteins expressed in the extracellular matrix (ECM) and have critical roles in tumor development and metastasis. However, the diverse expression patterns and prognostic roles of distinct THBS genes in gastric cancer have not been fully elucidated. In the current study, we aimed to investigate the expression patterns of THBSs in gastric cancer (GC) and determine whether they are prognostic markers for this malignancy. METHODS: mRNA expression status and genetic mutations of THBS family members were performed by using ONCOMINE, UCSC Xena browser, GEPIA, and cBioPortal databases. Prognostic values and function enrichment analysis of the members were assessed via Kaplan-Meier plotter and Metascape. RESULTS: we found that the mRNA expression of THBS1, THBS2, THBS4, and COMP were higher in patients with GC tissues than those in normal gastric mucosa and there was no difference in the mRNA expression of THBS3 between GC and normal tissue. Survival analysis revealed that mRNA levels of THBSs were strongly related to worse OS in GC patients (P<0.05). Overexpression of THBSs indicated poor OS in stage III/IV GC and high expression of THBS1, THBS3, THBS4, and COMP were related to worse OS in stage II GC. CONCLUSIONS: Bioinformatics analysis revealed a better understanding the value of THBS family members in GC and suggest that THBSs might serve as potential prognostic biomarkers for GC. 2021 Journal of Gastrointestinal Oncology. All rights reserved.
Authors: J Zachary Sanborn; Stephen C Benz; Brian Craft; Christopher Szeto; Kord M Kober; Laurence Meyer; Charles J Vaske; Mary Goldman; Kayla E Smith; Robert M Kuhn; Donna Karolchik; W James Kent; Joshua M Stuart; David Haussler; Jingchun Zhu Journal: Nucleic Acids Res Date: 2010-11-08 Impact factor: 16.971
Authors: Pietro Zoppoli; Giovanni Calice; Simona Laurino; Vitalba Ruggieri; Francesco La Rocca; Giuseppe La Torre; Mario Ciuffi; Elena Amendola; Ferdinando De Vita; Angelica Petrillo; Giuliana Napolitano; Geppino Falco; Sabino Russi Journal: J Clin Med Date: 2019-05-11 Impact factor: 4.241