Lia D Ernst1, Paul J Steffan, Priya Srikanth, Jack Wiedrick, David C Spencer, Proleta Datta, Navya M Joseph, Magda Wernovsky, Danielle A Becker. 1. Department of Neurology, Oregon Health & Science University (OHSU), Portland, Oregon, U.S.A.; Institute of Neuroscience, University of Oregon, Eugene, Oregon, U.S.A.; Department of Biostatistics, Oregon Health & Science University (OHSU), Portland, Oregon, U.S.A.; Department of Neurology, University of Nebraska Medical Center, Omaha, Nebraska, U.S.A.; and Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
Abstract
PURPOSE: Both vagal nerve stimulation (VNS) and responsive neurostimulation (RNS System) are treatment options for medically refractory focal epilepsy. The mechanism of action of both devices remains poorly understood. Limited prior evidence suggests that acute VNS stimulation may reduce epileptiform activity and cause EEG desynchronization on electrocorticography (ECoG). Our study aims to isolate effects of VNS on ECoG as recorded by RNS System in patients who have both devices, by comparing ECoG samples with and without acute VNS stimulation. METHODS: Ten 60-second ECoGs each from 22 individuals at 3 epilepsy centers were obtained-5 ECoGs with VNS "off" and 5 ECoGs with VNS "on." Electrocorticograps containing seizures or loss of telemetry connection artifact were excluded from analysis (total of 169 ECoGs were included). Electrocorticographs were analyzed for differences in spectral content by generating average spectrograms for "on" and "off" states and using a linear mixed-effects model to isolate effects of VNS stimulation. RESULTS: Acute VNS stimulation reduced average power in the theta band by 4.9%, beta band by 3.8%, and alpha band by 2.5%. The reduction in theta power reached statistical significance with a P value of <0.05. CONCLUSIONS: Our results provide evidence that acute VNS stimulation results in desynchronization of specific frequency bands (salient decrease in theta and beta bands, smaller decrease in alpha band) in ECoGs recorded by the RNS device in patients with dual (VNS and RNS) neurostimulators. This finding offers support for desynchronization as a theorized mechanism of action of VNS. Further research may lead to future improved neurostimulator efficacy by informing optimal stimulation programming parameters.
PURPOSE: Both vagal nerve stimulation (VNS) and responsive neurostimulation (RNS System) are treatment options for medically refractory focal epilepsy. The mechanism of action of both devices remains poorly understood. Limited prior evidence suggests that acute VNS stimulation may reduce epileptiform activity and cause EEG desynchronization on electrocorticography (ECoG). Our study aims to isolate effects of VNS on ECoG as recorded by RNS System in patients who have both devices, by comparing ECoG samples with and without acute VNS stimulation. METHODS: Ten 60-second ECoGs each from 22 individuals at 3 epilepsy centers were obtained-5 ECoGs with VNS "off" and 5 ECoGs with VNS "on." Electrocorticograps containing seizures or loss of telemetry connection artifact were excluded from analysis (total of 169 ECoGs were included). Electrocorticographs were analyzed for differences in spectral content by generating average spectrograms for "on" and "off" states and using a linear mixed-effects model to isolate effects of VNS stimulation. RESULTS: Acute VNS stimulation reduced average power in the theta band by 4.9%, beta band by 3.8%, and alpha band by 2.5%. The reduction in theta power reached statistical significance with a P value of <0.05. CONCLUSIONS: Our results provide evidence that acute VNS stimulation results in desynchronization of specific frequency bands (salient decrease in theta and beta bands, smaller decrease in alpha band) in ECoGs recorded by the RNS device in patients with dual (VNS and RNS) neurostimulators. This finding offers support for desynchronization as a theorized mechanism of action of VNS. Further research may lead to future improved neurostimulator efficacy by informing optimal stimulation programming parameters.
Authors: William L Schuerman; Kirill V Nourski; Ariane E Rhone; Matthew A Howard; Edward F Chang; Matthew K Leonard Journal: Sci Rep Date: 2021-11-23 Impact factor: 4.379
Authors: Mesha-Gay Brown; Stefan Sillau; Danielle McDermott; Lia D Ernst; David C Spencer; Dario J Englot; Hernán F J González; Proleta Datta; Ioannis Karakis; Danielle Becker; John D Rolston; Amir Arain; Vikram R Rao; Michael Doherty; Alexandra Urban; Cornelia Drees Journal: Epilepsy Behav Date: 2022-03-16 Impact factor: 3.337