COMMENTARY: Improving the prenatal diagnosis of Beckwith-Wiedemann syndrome.

When an omphalocele is identified on prenatal ultrasound, a number of differential diagnoses must be prioritized in the diagnostic work-up. After chromosomal abnormalities are excluded, the most common condition found is Beckwith-Wiedemann Syndrome (BWS)1, a complex imprinting disorder caused by disrupted expression of genes in the imprinted gene cluster on chromosome 11p15. 5 through a number of different mechanisms. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.