Franziska Püschner1, Sarah Wetzel2, Dominika Urbanski-Rini2, Nick Bertram2, Monika Schliffke3, Martin Göhl4, Carsten Petersen5. 1. Private Institute for Applied Health Services Research (inav GmbH), Schiffbauerdamm 12, 10117, Berlin, Germany. pueschner@inav-berlin.de. 2. Private Institute for Applied Health Services Research (inav GmbH), Schiffbauerdamm 12, 10117, Berlin, Germany. 3. Association of Statutory Health Insurance Physicians (KVSH), Schleswig-Holstein, Germany. 4. MSD SHARP & DOHME GmbH, Haar, Germany. 5. Docevent, Schleswig, Germany.
Abstract
PURPOSE: The aim of the study was to analyse health-related quality of life (HRQoL) and its determinants in individuals with an increased risk of developing type 2 diabetes mellitus (T2D). METHODS: We used pseudonymized baseline data collected between 2018 and 2020 as part of the Dimini project in Hesse and Schleswig-Holstein. HRQoL was measured by the mental and the physical component score of the validated instrument Short Form 12 and descriptively analysed followed by multiple linear regression analysis. RESULTS: The Dimini population (n = 662) showed an average physical component score of 42.12 (SD 10.56) and a mental component score of 47.12 (SD 11.13). While men demonstrated both significantly higher physical and mental component scores than women, differences based on migration background were not observed. Younger age was associated with a higher level of the physical component score, whereas mental component scores linearly increased with age. Regarding indicators of T2D-risk, a significant influence of HbA1c on HRQoL was not confirmed. However, physical component scores are negatively related to Findrisk scores and BMI. Finally, study participants living alone and those with a handicap reported lower levels of HRQoL. CONCLUSION: Compared with a representative sample of the general German population (DEGS1), Dimini participants were characterized by a lower average HRQoL. The analysis showed a higher vulnerability to an impaired HRQoL within certain subgroups of the population and among participants with relatively higher levels of T2D-risk. As a result, tailored healthcare interventions are required to reach these target groups. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov ID NCT03482674.
PURPOSE: The aim of the study was to analyse health-related quality of life (HRQoL) and its determinants in individuals with an increased risk of developing type 2 diabetes mellitus (T2D). METHODS: We used pseudonymized baseline data collected between 2018 and 2020 as part of the Dimini project in Hesse and Schleswig-Holstein. HRQoL was measured by the mental and the physical component score of the validated instrument Short Form 12 and descriptively analysed followed by multiple linear regression analysis. RESULTS: The Dimini population (n = 662) showed an average physical component score of 42.12 (SD 10.56) and a mental component score of 47.12 (SD 11.13). While men demonstrated both significantly higher physical and mental component scores than women, differences based on migration background were not observed. Younger age was associated with a higher level of the physical component score, whereas mental component scores linearly increased with age. Regarding indicators of T2D-risk, a significant influence of HbA1c on HRQoL was not confirmed. However, physical component scores are negatively related to Findrisk scores and BMI. Finally, study participants living alone and those with a handicap reported lower levels of HRQoL. CONCLUSION: Compared with a representative sample of the general German population (DEGS1), Dimini participants were characterized by a lower average HRQoL. The analysis showed a higher vulnerability to an impaired HRQoL within certain subgroups of the population and among participants with relatively higher levels of T2D-risk. As a result, tailored healthcare interventions are required to reach these target groups. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov ID NCT03482674.
Entities:
Keywords:
Health-related quality of life; Innovation fund; Lifestyle intervention; People at risk; Type 2 diabetes mellitus
Authors: E Jacobs; W Rathmann; T Tönnies; D Arendt; M Marchowez; L Veith; O Kuss; R Brinks; A Hoyer Journal: Diabet Med Date: 2019-08-27 Impact factor: 4.359
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