Maria Luisa Pardiñas1, Mar Nohales1, Elena Labarta1,2, José María De Los Santos1, Amparo Mercader1,2, José Remohí1,2, Ernesto Bosch1,2, Maria José De Los Santos3,4,5. 1. Instituto Valenciano de Infertilidad, IVI RMA, Valencia, Spain. 2. Fundación IVI, Biopolo, Iis Hospital la Le, Valencia, Spain. 3. Instituto Valenciano de Infertilidad, IVI RMA, Valencia, Spain. mariajose.delossantos@ivirma.com. 4. Fundación IVI, Biopolo, Iis Hospital la Le, Valencia, Spain. mariajose.delossantos@ivirma.com. 5. OB/GYN Department, University of Valencia, Valencia, Spain. mariajose.delossantos@ivirma.com.
Abstract
PURPOSE: Some women undergoing stimulated cycles have elevated serum progesterone (P) on the day of ovulation trigger, but its effect on embryo quality is unclear. We analyze embryo quality among patients with high and low serum P undergoing preimplantation genetic testing for aneuploidy (PGT-A). METHODS: This retrospective study included 1597 patients divided into two groups by serum P values: < 1.5 ng/mL or ≥ 1.5 ng/mL. A gonadotrophin-releasing hormone (GnRH) antagonist protocol was established for each patient. Serum P levels were measured on the day of triggering. Propensity score matching and Poisson regression were done. Age, body mass index, and ovarian sensitivity index were also compared. RESULTS: Elevated serum P was not significantly associated with euploid embryo rate or other embryo-quality variables evaluated in our study. Age was the only variable associated with euploidy rate (per MII oocyte, P < 0.001; per biopsied embryo, P = 0.008), embryo biopsy rate (P < 0.001), absolute number of euploid embryos (P = 0.008), and top-quality embryo rate (P = 0.008). Categorical variables decreased in value for every year of increased age in patients with high serum P. CONCLUSIONS: Elevated serum P did not affect the number of euploid and good-quality embryos for transfer in GnRH antagonist intracytoplasmic sperm injection (ICSI) cycles. Contrary to the clear influence of premature P elevation on endometrial receptivity based on literature, our results may help to tip the balance towards the absence of a negative effect of P elevation on embryo competence. More studies are needed to fully understand the effect of P elevation on reproductive outcomes.
PURPOSE: Some women undergoing stimulated cycles have elevated serum progesterone (P) on the day of ovulation trigger, but its effect on embryo quality is unclear. We analyze embryo quality among patients with high and low serum P undergoing preimplantation genetic testing for aneuploidy (PGT-A). METHODS: This retrospective study included 1597 patients divided into two groups by serum P values: < 1.5 ng/mL or ≥ 1.5 ng/mL. A gonadotrophin-releasing hormone (GnRH) antagonist protocol was established for each patient. Serum P levels were measured on the day of triggering. Propensity score matching and Poisson regression were done. Age, body mass index, and ovarian sensitivity index were also compared. RESULTS: Elevated serum P was not significantly associated with euploid embryo rate or other embryo-quality variables evaluated in our study. Age was the only variable associated with euploidy rate (per MII oocyte, P < 0.001; per biopsied embryo, P = 0.008), embryo biopsy rate (P < 0.001), absolute number of euploid embryos (P = 0.008), and top-quality embryo rate (P = 0.008). Categorical variables decreased in value for every year of increased age in patients with high serum P. CONCLUSIONS: Elevated serum P did not affect the number of euploid and good-quality embryos for transfer in GnRH antagonist intracytoplasmic sperm injection (ICSI) cycles. Contrary to the clear influence of premature P elevation on endometrial receptivity based on literature, our results may help to tip the balance towards the absence of a negative effect of P elevation on embryo competence. More studies are needed to fully understand the effect of P elevation on reproductive outcomes.
Authors: R Urrego; E Herrera-Puerta; N A Chavarria; O Camargo; C Wrenzycki; N Rodriguez-Osorio Journal: Theriogenology Date: 2014-12-30 Impact factor: 2.740
Authors: Carlos Hernandez-Nieto; Joseph A Lee; Tamar Alkon-Meadows; Martha Luna-Rojas; Tanmoy Mukherjee; Alan B Copperman; Benjamin Sandler Journal: Hum Reprod Date: 2020-08-01 Impact factor: 6.918
Authors: F Ubaldi; J Smitz; A Wisanto; H Joris; J Schiettecatte; M P Derde; E Borkham; A Van Steirteghem; P Devroey Journal: Hum Reprod Date: 1995-12 Impact factor: 6.918