Overcoming Barriers to the Effective Management of Severe Asthma in Italy.

INTRODUCTION: People with severe asthma (SA) often have poor disease control and quality of life, and are at high risk of exacerbations, lung function decline and asthma-related death. The present expert opinion article aimed to identify unmet needs in the management of SA in Italy, and propose possible solutions to address these needs.
METHODS: At five multidisciplinary events in Italy, attendees identified factors that interfered with the effective management of SA and suggested how these barriers could be overcome. A core group of 12 Italian experts (pulmonologists, general practitioners, allergists, payers and patients) identified the main issues and proposed possible solutions based on the results from the meetings and relevant articles from the literature. RESULTS AND
CONCLUSIONS: We reviewed the gap between real-world practice and guidelines, oral corticosteroid overuse, SA-related mortality, and barriers to effective SA treatment. Common themes were lack of awareness about SA among both patients and clinicians, and lack of networking/information exchange between those involved in the treatment of SA. Participants agreed on the need to implement patient education and create multidisciplinary groups of specialists to improve SA management through multidisciplinary educational initiatives, meetings with local experts, development of a flow chart for referral/connection with local experts and specialized centers. Clinical instruments that might help specialists improve SA management included referral networks, integrated care pathways, phenotyping and treatment algorithms, exacerbation tracking, and examination of electronic medical records for patients with uncontrolled asthma. The following actions need to be implemented in Italy: i) maximize the use of advanced therapies, eg, biologics; ii) increase/improve education for physicians and patients; iii) improve multidisciplinary communication and care coordination; iv) introduce regional and local protocols for SA diagnosis and treatment; and v) change the structure of healthcare services to reduce specialist waiting times and facilitate access to biologic therapies.

Introduction

Asthma is a chronic respiratory disease characterized by airway inflammation and airflow obstruction.1 Asthma affects more than 300 million people worldwide, of whom between 3.5% and 10.0% are believed to have severe asthma.2–5 Several definitions of severe asthma have been proposed over the years.6 Currently, it is defined as asthma that requires high-dose anti-inflammatory therapy to achieve disease control, or asthma that remains uncontrolled despite such therapy.3,6 Severe asthma is a heterogeneous condition and its natural history is poorly understood.1,3,7 A range of factors, including genetic predisposition, medical history, comorbidities, and smoking, appear to play a role in the development of severe asthma.3

According to the European Respiratory Society (ERS)/American Thoracic Society (ATS) guidelines,3 severe asthma is defined as the condition that requires regular use of high doses of inhaled corticosteroids (ICS) in combination with a second controller and/or systemic corticosteroids to be controlled, or that remains uncontrolled despite such treatment.3,14 The 2020 Global Initiative for Asthma (GINA) recommendations define this condition as difficult-to-treat asthma, while severe asthma is a subset of difficult-to-treat disease that remains uncontrolled despite treatment with maximal optimized therapy or that worsens if such treatment is withdrawn.1 These definitions assume that the differential diagnosis of asthma has been established, that comorbidities have been optimally treated, and that environmental factors and poor adherence or inhaler technique have been excluded as reasons for lack of control.14 Therefore, the definition of severe asthma requires repeated observations of ongoing symptoms in patients whose treatment has been optimized.

Severe asthma imposes a substantial burden on the patient, the healthcare system and society at large. Patients with severe asthma are more likely to have poorly controlled symptoms, decreased lung function and exacerbations than patients with mild or moderate asthma.3 Furthermore, patients with severe asthma, especially those with comorbidities or high peripheral eosinophil levels, often use systemic corticosteroids at high doses and frequencies, and therefore are at increased risk of developing corticosteroid-related adverse events.8,9 Severe asthma also has a negative effect on the patients’ emotional wellbeing, their relationships with friends and family, and on their career.10,11 Although severe asthma affects a minority of patients, it is responsible for most of the costs associated with this disease.12,13

The aim of the present expert opinion article was to identify unmet needs in the management of severe asthma in Italy, and to propose possible solutions for addressing these needs in the context of the Italian Health Service.

Methods

In 2018 and 2019, five macroregional events and one multidisciplinary group meeting were held, at which panels of Italian experts, including pulmonologists, general practitioners (GPs), allergists, National Health Service (NHS) payers and representatives of patients’ associations, discussed the diagnosis and treatment of patients with severe asthma. The meetings were organized according to geographic location, with participants from: Lombardy and Trentino-Alto Adige; Piedmont, Liguria and Aosta Valley; Sicily, Calabria and Basilicata; Lazio, Tuscany and Sardinia; and Campania and Apulia. Attendees were local allergists, pulmonologists, and GPs known to be experienced in the management of severe asthma. Attendees were invited to participate independently of the sponsoring pharmaceutical company, based on the physicians’ publication history, reputation and curriculum vitae. During the meetings, panels of experts (total n=58) and attendees (total n=127) were asked to identify the barriers that, in their opinion, interfered with the effective management of severe asthma and to suggest how these barriers could be overcome. At the end of the meetings, the attendees and panel of experts were asked to complete a written survey (n=86), designed to identify the impact of various barriers on patients with severe asthma. This survey was performed by an external Italian agency (Sentrix Global Health Communications Srl) well experienced in observational surveys, working in agreement with the current European regulations about the privacy of the collected opinions. This company is maintaining a copy of all documents. According to Italian regulations, this type of consultative research activity (similar to demoscopic assessment) does not require Ethics committee approval. Attendees were fully informed about the nature of the survey and the anonymity of the survey results in their invitation to the meeting. Consent to participate was implicit in their attendance at the meeting. The authors of the present manuscript had access only to anonymous mean or median data.

In order to place the information gathered from the expert meetings in context, a review of relevant literature was conducted. Results from the macroregional events and relevant articles were discussed by the multidisciplinary group of 12 Italian experts, including pulmonologists, GPs, allergists, NHS payers and representatives of patients’ associations. Based on this discussion and after reaching a general consensus, the main issues were identified and possible solutions were proposed.

No statistical analysis was necessary, considering the descriptive nature of the article.

Results

Based on the results of the literature review and the discussions at the macroregional events, the following issues were identified.

Gap Between Real-World Practice and Guideline Recommendations

Recommended Management of Severe Asthma

According to the GINA guidelines,1 the recommended approach to the management of difficult-to-treat asthma includes several steps: i) evaluation of the patient’s adherence to the recommended treatment and the correct use of inhalers, considering the possibility of switching to ICS-formoterol as maintenance and reliever therapy; ii) verification that the diagnosis of asthma has been performed correctly considering the typical asthma symptoms and risk factors, as well as demonstration of a variable airway obstruction; iii) evaluation and appropriate management of any comorbidities potentially responsible for poor asthma control; iv) avoidance or minimization of the trigger factors (eg allergen exposure, environmental or occupational pollutants, and smoking); and v) optimization of treatment with currently available inhaled drugs (ie, ICS, long-acting β2-agonist, long-acting muscarinic antagonist). If the patient remains uncontrolled at the end of this complex process of assessment (which may require several weeks or months to complete), then he or she should be considered to have severe uncontrolled asthma and should undergo the following steps: i) pheno-endotyping of asthma that takes into consideration clinical history, comorbidities and biomarkers; ii) in the case of a type 2 pattern of inflammation, treatment with biologic drugs should be considered. The biologic agents that are currently available for the treatment of severe asthma are monoclonal antibodies that target immunoglobulin E (omalizumab), interleukin (IL)-5 (mepolizumab), IL-5 receptor α (benralizumab), or the IL-4 receptor (dupilumab).15 While these agents provide a highly effective treatment option for many patients with severe asthma,16–19 their high cost means that they should be reserved for those most likely to benefit. Unfortunately, very few treatment options (and in particular, no biologic drugs) are currently available for patients with severe asthma who have non-type 2 inflammation, and these patients have a poor prognosis. In these patients, low-dose oral corticosteroids (OCS) can be considered as second-line add-on therapy, although special attention is needed to minimize adverse effects.1

After a treatment has been started, frequent assessment of its efficacy in terms of improving symptoms, reducing the exacerbation rate, and improving pulmonary function and quality of life should be performed in order to verify that the treatment is appropriate and to determine whether it should be continued. However, if the efficacy of the treatment regimen is inadequate, a switch to another alternative may be required.

Management of Severe Asthma in Real-World Practice

There is reason to believe that guideline recommendations are not followed in real-world clinical practice.20,21 In a study that included 107 Italian GPs and 995 patients with asthma, 28.8% of patients received treatment that adhered to the 2009 GINA guidelines.20 In this study, the use of guideline-compliant treatment was significantly associated with disease control.20

Studies consistently find that asthma is poorly controlled in a large proportion of patients.22,23 The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR I) study provided important insights into the epidemiology and outcomes of patients aged >6 years with severe or difficult-to-treat asthma.24 The TENOR I study included 807 patients with very poorly controlled asthma, as defined in the 2007 National Heart, Lung, and Blood Institute (NHLBI) guidelines; only a small proportion of these patients showed improvement over 24 months, with 62.2% of children (6–11 years old) and 75.0% of adolescents and adults (≥12 years old) having consistently very poorly controlled asthma during follow up.24 Subsequently, the TENOR II study, which followed 341 patients from the TENOR 1 study for >10 years, showed that the majority of patients continued to have very poorly controlled asthma during this long-term follow-up period.25

Poor disease control in patients with asthma is associated with a number of adverse outcomes, such as increased risk of unscheduled office visits, OCS bursts, emergency room visits and hospitalizations, and worsening quality of life and general health status.26,27 Data from the Italian Severe Asthma Registry support these findings, and show that an increased rate of exacerbations, lung function decline, and corticosteroid-induced morbidity and mortality are associated with poor control of severe asthma in Italian patients.7,28

Overuse of Oral Corticosteroids

A major issue in the management of asthma, and particularly severe asthma, is the overuse of OCS treatment.14 The GINA guidelines have always listed low-dose OCS as an option for add-on therapy in patients with severe asthma, but from 2014, low-dose OCS was recommended as a second-line therapy in this setting, with biologic therapy being the preferred option.15 In addition, from 2019, the GINA guidelines noted that physicians should consider the adverse effects of low-dose OCS when prescribing them for severe asthma.16 The adverse events known to be associated with OCS include hypertension, osteoporosis and bone fracture, cataract and glaucoma, diabetes, respiratory infections, reduced growth velocity in children, and hypothalamic-pituitary-adrenal axis suppression.13 A study of long-term medical records from 24,117 adult patients with asthma treated with systemic corticosteroids who were matched with an equal number of patients with no systemic corticosteroid exposure showed that systemic corticosteroids were associated with a significantly higher risk of osteoporosis and bone fracture, pneumonia, cardio- or cerebrovascular disease, cataracts, sleep apnea, renal impairment, depression or anxiety, type 2 diabetes, and bodyweight gain.17 The risk of these adverse events increased in a dose-dependent manner.17 Two systematic literature reviews reported similar findings, and also provided evidence that a higher dose and duration of systemic corticosteroid treatment are associated with increased healthcare costs.18,19

OCS are widely used in patients with severe asthma in Italy. For example, in a study of 437 consecutive patients with severe asthma from the Severe Asthma Network in Italy (SANI), 64.1% were prescribed OCS.20 Another study conducted in a cohort of Italian patients with severe asthma, who were identified using the Health Search Database from GPs, found that 76.1% received OCS at the time of diagnosis.21 In Italy, the annual healthcare costs per patient due to OCS-related adverse events have been estimated at €1957.50 for severe asthma, compared with €1350.96 for mild or moderate asthma.13 Based on an estimated 199,980 patients with severe asthma in Italy, the total annual healthcare costs associated with OCS-related adverse events were calculated to be €242.7 million.13,20 The adverse events and costs of OCS explain why, since 2019, the GINA guidelines have recommended that these agents should be used only as a second-line option for patients with severe asthma who do not respond to, or are unable to take, other options such as biologic agents.1,16

Preventable Mortality

Although deaths due to asthma declined in most countries by approximately 50% between 2001–2005 and 2011–2015, it is estimated that in 2016 there were 420,000 asthma-related deaths worldwide.2 Many asthma-related deaths are believed to be preventable and result from a lack of appropriate treatment.22–24 In the United Kingdom (UK), approximately 40% of asthma-related deaths are thought to have occurred in patients with severe asthma.24 Furthermore, long-term OCS use in these patients is associated with an increased risk of mortality.25,26

Barriers to Effective Management of Severe Asthma

The GINA guidelines emphasize the importance of patients’ goals and satisfaction in the effective management of asthma.1 Recently, a group of academics, patient advocates, and representatives from professional organizations developed a Charter for the Care of Patients with Severe Asthma, with the goal of improving the quality of care for this condition.27 The charter includes six principles that are intended to outline what patients with severe asthma should expect from treatment and what should constitute a basic standard of care (Table 1).27 Nevertheless, a number of barriers prevent patients achieving optimal care.28–34

Table 1

Charter to Improve Patient Care in Severe Asthma

Principle
1	I deserve a timely, straightforward referral when my severe asthma cannot be managed in primary care.
2	I deserve a timely, formal diagnosis of my severe asthma by an expert team.
3	I deserve support to understand my type of severe asthma.
4	I deserve care that reduces the impact of severe asthma on my daily life and improves my overall quality of care.
5	I deserve not to be reliant on oral corticosteroids.
6	I deserve to access consistent quality care, regardless of where I live or where I choose to access it.

Note: Data from Menzies-Gow et al.27

Barriers to Severe Asthma Diagnosis and Management in Italy

The barriers to effective diagnosis and management of severe asthma in Italy that were identified during the five multidisciplinary meetings are presented in Table 2. These barriers were classified based on whether they impacted mostly GPs and specialists, patients and caregivers, or healthcare providers, and whether they related to diagnosis, management, or follow-up. Two common themes emerged from the discussion: i) lack of awareness about severe asthma among both patients and clinicians, and ii) lack of networking and information exchange between those involved in the treatment of severe asthma. The findings of the short survey that was conducted to explore the impact of specific barriers are presented in Table 3.

Table 2

Barriers to Effective Management of Severe Asthma in Italy According to Various Stakeholders

Barriers to Correct and Timely Diagnosis
According to GPs and pulmonary specialists	Failure to identify severe asthma
	Failure/delayed referral to a specialist by GPs
	Poor communication between GPs, specialists and first aid providers
	Lack of awareness of severe asthma among clinicians
According to patients and/or caregivers	Lack of patient awareness and self-management
	Poor treatment adherence
According to health system providers	Poorly structured clinics
	Long waiting lists
	Lack of collaboration between various specialists
	Lack of awareness of severe asthma in the wider society
Barriers to Effective Therapeutic Management
According to GPs and pulmonary specialists	Underuse and poor availability of biomarkers to guide treatment decisions
	Absence of an OCS-use monitoring system
	Underuse of phenotyping by specialists
	Treatment of acute phases only
	Failure to check adherence to therapy
According to patients and/or caregivers	Poor patient education and empowerment
	Fear of having to resort to using systemic corticosteroids
According to health system providers	Cost of biologic drugs
	Lack of real-world epidemiological data in Italy
	Absence of a structured network and lack of collaboration between GPs, specialist prescribers of biologic agents, and non-prescribing specialists
	Lack of key performance indicators
Barriers to Effective Follow-Up
According to GPs and pulmonary specialists	Lack of follow-up planning
	Poor communication about follow-up schedule and poor GP involvement
	Underuse of biomarkers to guide treatment decisions
According to patients and/or caregivers	Lack of trust between patients and clinicians
	Poor treatment adherence
According to health system providers	Absence of a structured network and lack of collaboration between GPs, specialist prescribers of biologic agents and non-prescribing specialists
	Logistic difficulties (distribution of centers in the area)
	Scarcity of economic and personnel resources
	Lack of key performance indicators

Abbreviations: GP, general practitioner; OCS, oral corticosteroids.

Table 3

The Impact of Various Barriers to Effective Management of Severe Asthma (Survey Results)

Barriers	Major Consequences
Delay in referral to a center with special expertise in the field of severe asthma	Risk of serious exacerbations
	Decreased quality of life
	Late diagnosis
Incorrect diagnosis	Risk of serious exacerbations
	Decreased quality of life
	Inappropriate treatment
Late diagnosis	Risk of serious exacerbations
	Decreased quality of life
	Disease progression/airway remodeling
	Increased mortality risk
Delay/failure to attend follow-up after receiving first aid treatment	Risk of serious exacerbations
	Inappropriate use of OCS
	Absence of monitoring of the number and severity of exacerbations
Absence of an OCS-use monitoring system	OCS overuse
	Adverse effects related to OCS use
	Delay in using alternative therapies
Lack/poor access to diagnostic tests	Late/incorrect diagnosis
	Inappropriate treatment
	Poor asthma control

Abbreviation: OCS, oral corticosteroids.

Possible Solutions

The measures suggested by participants for addressing the various barriers are listed in Table 4. All participants agreed on the need to create a multidisciplinary group of specialists in order to improve the management of patients with severe asthma and to implement patient education. This should be achieved by educational initiatives for multidisciplinary teams, meetings with local experts, instruments for the creation of a flow chart for referral or connection with local experts, and sessions to improve knowledge in specialized centers. Several clinical instruments are believed to be useful for specialists in improving the management of severe asthma: referral networks, integrated care pathways, phenotyping and treatment algorithms, tracking of exacerbations, and examination of electronic medical records for patients with uncontrolled asthma. Multidisciplinary networks and specific routes of referral should be organized and implemented in clinical practice in each area of Italy.

Table 4

Suggestions for Overcoming the Barriers to Effective Management of Severe Asthma

Target Audience	Suggestions
Pulmonary/allergy centers with the authority to prescribe biologic drugs	Creating dedicated agendas and preferential channels for patients with severe asthma
	Establishing a diagnostic-therapeutic pathway for severe asthma
	Conducting interdisciplinary internal meetings (otolaryngologist, psychologists, gastroenterologists, interventionists)
	Keeping clinical registries to support the network among centers
Pulmonologists/allergists without the authority to prescribe biologic drugs	Establishing collaboration between GPs/specialists who can prescribe biologic agents and specialists who cannot prescribe biologic agents
	Conducting regular training on referral criteria
	Conducting training to become a prescribing center
	Collaborating with specialists who treat comorbidities
Patients and caregivers	Improving public awareness of severe asthma
	Education about severe asthma in schools
	Supporting patients’ associations
	Providing support for scientific societies
GPs	Conducting refresher courses on severe asthma
	Creating a network with specialist centers
	Providing GPs with objective parameters for recognizing severe asthma (flow charts, alerts for indicators of uncontrolled asthma)
	Training in spirometry and diagnostic techniques
Emergency units	Improving identification of patients with severe asthma and facilitating their referral to appropriate specialists
	Improving training on how to recognize severe asthma
	Promoting collaboration within hospitals
	Promoting collaboration between first aid providers and biologic prescribing centers
Hospital pharmacists	Increasing the involvement of hospital pharmacists in the management of severe asthma
	Taking advantage of big data available to pharmacists (eg about over-prescription of OCS)
	Conducting video tutorials in pharmacies
	Providing spirometry assessments in hospital pharmacies
Payers	Establishing outpatient clinics dedicated to asthma
	Implementing Integrated Care Pathways
	Collection of Italian epidemiological data and conducting pharmacoeconomic analyses on the use of biologics
	Establishing regional networks
All target audiences	Creating a hub-and-spoke/collaborative network
	Providing preferential channels for specialist visits for patients with severe asthma
	Creating a network connecting all stakeholders at the regional level
	Imitating existing local best practices

Abbreviations: GP, general practitioner; OCS, oral corticosteroids.

Expert Opinion on Addressing Barriers to Effective Management of Severe Asthma in the Context of the Italian Health Service

We suggest several solutions to improve disease control, reduce the risks associated with poor asthma control, optimize healthcare resource utilization, and implement the Charter in the context of the Italian Health Service. These potential solutions take into consideration the results of discussions held during the macroregional events.

Considering that the use of OCS is often associated with adverse events, therapeutic strategies that reduce the need for OCS, while also achieving asthma control, should be adopted.7,35 The biologic therapies targeting the IL-5/IL-5Rα and IL-4 pathways have been shown to reduce the maintenance dose of OCS in patients with severe asthma.36–39

Better adherence to treatment guidelines, particularly with respect to ICS, should be encouraged.16,40,41

Medical education should focus on the correct application of asthma treatment guidelines in order to overcome unnecessary prescriptions. Patients should be informed about the correct inhaler technique and provided with medical information to enable them to understand the nature of their condition and treatments.1 An improvement in communication and care coordination between GPs and specialists may help to increase diagnostic and treatment capacities in primary care, improve referral, promote better use of specialist asthma centers, and ensure the more timely and appropriate prescription of biologic therapy. Many patients with asthma overestimate the extent of their asthma control.42 Therefore, central to the primary care management of asthma is a thorough understanding by GPs of what constitutes asthma control, so that all patients who are not achieving control can be promptly identified and the reasons for poor control identified. Patient adherence should be thoroughly investigated, and patients should be evaluated for attitudes and beliefs that may be negatively impacting adherence, as well as other factors, such as depression, anxiety, or substance abuse.28,33

Regional health systems should introduce better diagnostic and therapeutic pathways, and GPs and specialists should be provided with diagnostic algorithms designed specifically for severe asthma. There should be dedicated treatment pathways for patients with severe asthma, ideally involving referral to a specialist center, where these patients can be managed by a multidisciplinary team experienced in complex asthma management. Such centers are best placed to ensure that patients undergo phenotypic assessment and receive prompt treatment with the most appropriate agent for their asthma.

Healthcare is publicly funded in Italy and organized regionally, which can lead to differences in healthcare access between regions. The Charter described above recommends consistent and universal access to healthcare for all patients with severe asthma, which requires a coordinated approach overseen at the national level. Therefore, a Population Health Management approach should be introduced to improve clinical and financial outcomes in severe asthma. Individual patients should be monitored and data should be aggregated. Relevant clinical data should be shared by GPs, specialists and hospitals. The use of population-level data with treatment outcomes is expected to produce actionable analytics for providers that would help improve efficiency and patient care at a regional and local level. Effective division of labor, between specialists who are responsible for planning therapeutic interventions and GPs who are in charge of follow-up, should be promoted. Specialists should not be concentrated in single centers, but should move according to patients’ needs.

Minimal requirements for asthma centers should be formulated.

Payers should be involved in improving healthcare system organization and reducing waiting times for specialist consultation.

Pharmacoeconomic analyses should be performed to support all initiatives in this field to identify the most cost-effective approaches to comprehensive patient care.

Managing Severe Asthma Patients During the COVID-19 Pandemic

Beginning in early 2020, the world has been facing a new pandemic caused by the SARS-CoV-2 virus (COVID-19), which causes severe acute respiratory syndrome. Patients with asthma are at risk of experiencing exacerbations triggered by COVID-19 infection.43 GINA,44 the UK National Institute for Health and Care Excellence (NICE),45 and the Italian Associazione Allergologi Immunologi Italiani Territoriali e Ospedalieri (AAITO)46 and Societa’ Italiana di Allergologia, Asma ed Immunologia Clinica (SIAAIC)47 guidelines recommend that i) patients should avoid accessing hospitals to reduce their risk of becoming infected; ii) patients should continue to receive ICS, OCS, or biologic therapies as prescribed and treatment interruptions should be avoided; and iii) if possible, patients should self-administer treatments at home after receiving appropriate training and written instructions.44,45 Thus, patients with severe asthma who are receiving biologic treatments should continue the treatment by self-administration, whenever possible.44–47

The COVID-19 pandemic will have a profound impact on modern medicine and is already reshaping the patient–physician relationship. A number of measures can be implemented to protect patients with asthma, as described in an article detailing the experience of physicians at the Allergy Clinic of the Humanitas Research Hospital in Milan, Italy.48 COVID-19-free zones were established to reduce within-hospital transmission. Before entering these zones, patients were screened for signs of active infection, underwent hand sanitization procedures, and were provided with surgical masks. Patients with severe or uncontrolled asthma were instructed to arrive for their scheduled appointments at predetermined times and to maintain social distancing. On the other hand, patients with mild-to-moderate symptoms or well-controlled disease were transitioned to a telemedicine service that included phone, video, and email consultations. Patients were asked to self-administer biologic drugs that were delivered to their homes.48 Hospitals treating patients with asthma should implement these or similar measures, depending on local circumstances, in order to maintain disease control in patients with asthma and reduce the risk of exacerbations that may necessitate hospitalization.43

Conclusions

In Italy, as in other European countries, severe asthma places a significant burden on patients, healthcare systems, and society. Therefore, it is important to ensure effective management of this condition, which is hindered by several unmet needs. These include poor disease control and adherence to clinical practice guidelines, treatment-related adverse events, and adverse health outcomes, which may include asthma-related death in some cases. In order to address these unmet needs in Italy and to meet the Charter for patient care, it is necessary to implement a series of actions: i) decrease the burden of inappropriate OCS usage by maximizing the use of advanced therapies, such as biologic drugs; ii) increase education efforts targeted at physicians and patients; iii) improve multidisciplinary communication and care coordination, to accelerate referral and severe asthma diagnosis and pheno-endotyping; iv) introduce diagnostic and therapeutic protocols for severe asthma at the regional or local level; and v) establish cost-effective structural changes to healthcare services, reducing waiting times for specialist consultation and facilitating access to targeted biologic therapies.