Suzanne Dufresne1, Jordan Guéritat1, Carmen P Wong2,3, Amin Isanejad1, Emily Ho2,3,4, Eva Serna5, Marie-Carmen Gomez-Cabrera5, Amélie Rebillard6. 1. University of Rennes, M2S-EA7470, Rennes, France. 2. School of Biological & Population Health Sciences, College of Public Health & Human Sciences, 211 Milam Hall, Oregon State University, Corvallis, OR, USA. 3. Linus Pauling Institute, Oregon State University, 307 Linus Pauling Science Center, Corvallis, OR, USA. 4. Moore Family Center for Whole Grain Foods, Nutrition & Preventive Health, Oregon State University, Corvallis, OR, USA. 5. Freshage Research Group, Department of Physiology, University of Valencia, CIBERFES, INCLIVA, Valencia, Spain. 6. University of Rennes, M2S-EA7470, Rennes, France. amelie.rebillard@univ-rennes2.fr.
Abstract
BACKGROUND: Exercise is increasingly recognized as an effective strategy to improve cancer prevention and prognosis. Several biological mechanisms mediating these benefits have been proposed, but the role of epigenetics remains largely unknown. Since epigenetics is highly susceptible to lifestyle factors, we hypothesized that exercise could affect the epigenome landscape in cancer tissues. METHODS: Rats implanted with AT1 prostate tumors were randomized to either control or exercise training. microRNA expression, DNA methylation and histone acetylation were analyzed in the tumor tissue. RESULTS: MiR-27a-5p appeared to be differently expressed between sedentary and trained rats. Furthermore, exercise increased global DNA methylation and decreased DNA methyltransferases mRNA expression in the tumor tissue. Histone acetylation however remained unaltered. CONCLUSION: Overall, exercise might reverse some of the cancer-related epigenetic alterations in the prostate tumor tissue.
BACKGROUND: Exercise is increasingly recognized as an effective strategy to improve cancer prevention and prognosis. Several biological mechanisms mediating these benefits have been proposed, but the role of epigenetics remains largely unknown. Since epigenetics is highly susceptible to lifestyle factors, we hypothesized that exercise could affect the epigenome landscape in cancer tissues. METHODS: Rats implanted with AT1 prostate tumors were randomized to either control or exercise training. microRNA expression, DNA methylation and histone acetylation were analyzed in the tumor tissue. RESULTS: MiR-27a-5p appeared to be differently expressed between sedentary and trained rats. Furthermore, exercise increased global DNA methylation and decreased DNA methyltransferases mRNA expression in the tumor tissue. Histone acetylation however remained unaltered. CONCLUSION: Overall, exercise might reverse some of the cancer-related epigenetic alterations in the prostate tumor tissue.
Authors: R Zelic; V Fiano; C Grasso; D Zugna; A Pettersson; A Gillio-Tos; F Merletti; L Richiardi Journal: Prostate Cancer Prostatic Dis Date: 2014-11-11 Impact factor: 5.554
Authors: Carmen Jerónimo; Patrick J Bastian; Anders Bjartell; Giuseppina M Carbone; James W F Catto; Susan J Clark; Rui Henrique; William G Nelson; Shahrokh F Shariat Journal: Eur Urol Date: 2011-06-22 Impact factor: 20.096
Authors: Srinivasan Yegnasubramanian; Michael C Haffner; Yonggang Zhang; Bora Gurel; Toby C Cornish; Zhijin Wu; Rafael A Irizarry; James Morgan; Jessica Hicks; Theodore L DeWeese; William B Isaacs; G Steven Bova; Angelo M De Marzo; William G Nelson Journal: Cancer Res Date: 2008-11-01 Impact factor: 12.701