Zhao Tian1, Yi-Chao Zhang2, Yue Wang1, Xiao-Hong Chang1, Hong-Lan Zhu3, Yan Zhao1. 1. Department of Obstetrics and Gynecology, People's Hospital, Peking University, Beijing, China. 2. Department of Digestive Surgery, Xijing Hospital, Xi'an Medical University, Xi'an, China. 3. Department of Obstetrics and Gynecology, People's Hospital, Peking University, Beijing, China. Electronic address: honglanzhu01@163.com.
Abstract
BACKGROUND: Bariatric surgery is effective for polycystic ovary syndrome (PCOS), while the exact mechanism remains unclear. OBJECTIVES: To assess the impact of bariatric surgery on PCOS patients and further explore the possible mechanism. SETTING: A meta-analysis. METHODS: We searched PubMed, Web of Science, The Cochrane Library, and Embase to identify relevant studies published before November 2020. RESULTS: Twenty-one studies met our inclusion criteria, and we identified 552 patients with PCOS study. Results showed that the prevalence of preoperative PCOS, menstrual irregularity, hirsutism, type 2 diabetes (T2D), hypertension, infertility, and depression significantly decreased after bariatric surgery. Levels of total testosterone, fasting insulin, and luteinizing hormone (LH) decreased and estradiol increased, while levels of follicle-stimulating hormone (FSH) and LH/FSH did not show significant changes during the 3-month follow-up. There were decreases in testosterone and fasting insulin levels when the postoperative follow-up time was 6 months or ≥12 months. Levels of fasting blood glucose and triglycerides were significantly reduced after 6 months or ≥12 months of bariatric surgery. High-density lipoprotein (HDL) and sex hormone-binding globulin (SHBG) significantly improved ≥12 months after bariatric surgery. CONCLUSION: Symptoms of PCOS and related complications are significantly alleviated after bariatric surgery. In addition, we found a significant improvement on anomalous secretion of gonadotropins, glucose metabolism, and lipid metabolism in patients with PCOS after bariatric surgery.
BACKGROUND: Bariatric surgery is effective for polycystic ovary syndrome (PCOS), while the exact mechanism remains unclear. OBJECTIVES: To assess the impact of bariatric surgery on PCOSpatients and further explore the possible mechanism. SETTING: A meta-analysis. METHODS: We searched PubMed, Web of Science, The Cochrane Library, and Embase to identify relevant studies published before November 2020. RESULTS: Twenty-one studies met our inclusion criteria, and we identified 552 patients with PCOS study. Results showed that the prevalence of preoperative PCOS, menstrual irregularity, hirsutism, type 2 diabetes (T2D), hypertension, infertility, and depression significantly decreased after bariatric surgery. Levels of total testosterone, fasting insulin, and luteinizing hormone (LH) decreased and estradiol increased, while levels of follicle-stimulating hormone (FSH) and LH/FSH did not show significant changes during the 3-month follow-up. There were decreases in testosterone and fasting insulin levels when the postoperative follow-up time was 6 months or ≥12 months. Levels of fasting blood glucose and triglycerides were significantly reduced after 6 months or ≥12 months of bariatric surgery. High-density lipoprotein (HDL) and sex hormone-binding globulin (SHBG) significantly improved ≥12 months after bariatric surgery. CONCLUSION: Symptoms of PCOS and related complications are significantly alleviated after bariatric surgery. In addition, we found a significant improvement on anomalous secretion of gonadotropins, glucose metabolism, and lipid metabolism in patients with PCOS after bariatric surgery.
Authors: Helene A Fachim; Zohaib Iqbal; J Martin Gibson; Ivona Baricevic-Jones; Amy E Campbell; Bethany Geary; Akheel A Syed; Antony Whetton; Handrean Soran; Rachelle P Donn; Adrian H Heald Journal: Cells Date: 2021-10-19 Impact factor: 6.600