Literature DB >> 34006390

The Nexus of cfDNA and Nuclease Biology.

Diana S C Han1, Y M Dennis Lo2.   

Abstract

Cell-free DNA (cfDNA) is a widely used noninvasive biomarker for diagnosis and prognosis of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive waste products of cell death but could have a physiological and pathological function in inflammation and autoimmunity. The balance of cfDNA generation and clearance may thus be vital in health and disease. In particular, plasma nuclease activity has been linked to multiple pathologies including cancer and systemic lupus erythematosus (SLE) and associated with profound changes in the nonrandom fragmentation of cfDNA. Lastly, in this review, we explore the effects of DNA fragmentation factor B (DFFB), DNASE1L3, and DNASE1 on cfDNA levels and their fragmentomic profiles, and what these recent insights reveal about the biology of cfDNA.
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  DFFB; DNASE1; DNASE1L3; cell-free DNA; liquid biopsy; nuclease

Year:  2021        PMID： 34006390     DOI： 10.1016/j.tig.2021.04.005

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  13 in total

1.  Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics.

Authors:  Laura Kananen; Mikko Hurme; Alexander Bürkle; Maria Moreno-Villanueva; Jürgen Bernhardt; Florence Debacq-Chainiaux; Beatrix Grubeck-Loebenstein; Marco Malavolta; Andrea Basso; Francesco Piacenza; Sebastiano Collino; Efstathios S Gonos; Ewa Sikora; Daniela Gradinaru; Eugene H J M Jansen; Martijn E T Dollé; Michel Salmon; Wolfgang Stuetz; Daniela Weber; Tilman Grune; Nicolle Breusing; Andreas Simm; Miriam Capri; Claudio Franceschi; Eline Slagboom; Duncan Talbot; Claude Libert; Jani Raitanen; Seppo Koskinen; Tommi Härkänen; Sari Stenholm; Mika Ala-Korpela; Terho Lehtimäki; Olli T Raitakari; Olavi Ukkola; Mika Kähönen; Marja Jylhä; Juulia Jylhävä
Journal:  Geroscience       Date:  2022-07-21       Impact factor: 7.581

Review 2.  A practical guide to chimerism analysis: Review of the literature and testing practices worldwide.

Authors:  Amanda G Blouin; Fei Ye; Jenifer Williams; Medhat Askar
Journal:  Hum Immunol       Date:  2021-08-14       Impact factor: 2.211

3.  Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

Authors:  Meihui Chen; Rebecca W Y Chan; Peter P H Cheung; Meng Ni; Danny K L Wong; Ze Zhou; Mary-Jane L Ma; Liangbo Huang; Xinzhou Xu; Wing-Shan Lee; Guangya Wang; Kathy O Lui; W K Jacky Lam; Jeremy Y C Teoh; Chi-Fai Ng; Peiyong Jiang; K C Allen Chan; Rossa W K Chiu; Y M Dennis Lo
Journal:  PLoS Genet       Date:  2022-07-06       Impact factor: 6.020

4.  Genomic instability genes in lung and colon adenocarcinoma indicate organ specificity of transcriptomic impact on Copy Number Alterations.

Authors:  Chinthalapally V Rao; Chao Xu; Yuting Zhang; Adam S Asch; Hiroshi Y Yamada
Journal:  Sci Rep       Date:  2022-07-11       Impact factor: 4.996

Review 5.  Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases.

Authors:  Gustaf Wigerblad; Mariana J Kaplan
Journal:  Nat Rev Immunol       Date:  2022-10-18       Impact factor: 108.555

6.  B cell-derived cfDNA after primary BNT162b2 mRNA vaccination anticipates memory B cells and SARS-CoV-2 neutralizing antibodies.

Authors:  Ilana Fox-Fisher; Sheina Piyanzin; Mayan Briller; Esther Oiknine-Djian; Or Alfi; Roni Ben-Ami; Ayelet Peretz; Daniel Neiman; Bracha-Lea Ochana; Ori Fridlich; Zeina Drawshy; Agnes Klochendler; Judith Magenheim; Danielle Share; Ran Avrahami; Yaarit Ribak; Aviv Talmon; Limor Rubin; Neta Milman; Meital Segev; Erik Feldman; Yuval Tal; Shai S Shen-Orr; Benjamin Glaser; Ruth Shemer; Dana Wolf; Yuval Dor
Journal:  Med (N Y)       Date:  2022-05-19

7.  Effects of nucleases on cell-free extrachromosomal circular DNA.

Authors:  Sarah Tk Sin; Jiaen Deng; Lu Ji; Masashi Yukawa; Rebecca Wy Chan; Stefano Volpi; Augusto Vaglio; Paride Fenaroli; Paola Bocca; Suk Hang Cheng; Danny Kl Wong; Kathy O Lui; Peiyong Jiang; K C Allen Chan; Rossa Wk Chiu; Y M Dennis Lo
Journal:  JCI Insight       Date:  2022-04-22

Review 8.  Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression.

Authors:  Ludmila Alekseeva; Nadezhda Mironova
Journal:  Int J Mol Sci       Date:  2021-11-12       Impact factor: 5.923

9.  Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy.

Authors:  Ying Chen; Yonglin Wang; Xianfang Jiang; Jinhong Cai; Yuting Chen; Hanji Huang; Yuan Yang; Li Zheng; Jinmin Zhao; Ming Gao
Journal:  Bioact Mater       Date:  2022-03-28

10.  Circulating cell free DNA and citrullinated histone H3 as useful biomarkers of NETosis in endometrial cancer.

Authors:  Livia Ronchetti; Irene Terrenato; Enrico Vizza; Giulia Piaggio; Aymone Gurtner; Margherita Ferretti; Giacomo Corrado; Frauke Goeman; Sara Donzelli; Chiara Mandoj; Roberta Merola; Ashanti Zampa; Mariantonia Carosi; Giovanni Blandino; Laura Conti; Anna Maria Lobascio; Marcello Iacobelli
Journal:  J Exp Clin Cancer Res       Date:  2022-04-21
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