| Literature DB >> 34003780 |
Yulei Zhao1, Jenny Y Xue1,2, Piro Lito3,2,4,5.
Abstract
Guanine nucleotide exchange factors (GEF) control the rate-limiting step of physiologic RAS activation. In this issue of Cancer Discovery, Hofmann and colleagues describe the discovery of a selective inhibitor targeting the GEF, SOS1, along with its preclinical effects in suppressing KRAS-mutant tumor growth.See related article by Hofmann et al., p. 142. ©2021 American Association for Cancer Research.Entities:
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Year: 2021 PMID： 34003780 DOI： 10.1158/2159-8290.CD-20-1331
Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397