Richard A Hubner1, Helen L Reeves2, Julien Edeline3. 1. Department of Medical Oncology, The Christie NHS Foundation Trust/Division of Cancer Sciences, University of Manchester, Manchester, UK. 2. Newcastle University Translational and Clinical Research Institute, Newcastle University and The Liver Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. 3. Department of Medical Oncology, Centre Eugène Marquis, Rennes, France.