Elham Amjad1, Solmaz Asnaashari1, Babak Sokouti2. 1. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. b.sokouti@gmail.com.
Abstract
BACKGROUND: One of the well-differentiated types of thyroid cancer is papillary thyroid cancer (PTC), often developed by genetic mutations and radiation. METHODS: In this study, the public NCBI-GEO database was systematically searched. The eligible datasets were the targets for biomarker discovery associated with PI3K signaling pathway. RESULTS: Only two datasets were suitable and passed the inclusion criteria. The meta-analysis outcomes revealed eleven upregulation and thirteen downregulation genes differentially expressed between PTC and healthy tissues. Moreover, the outcomes for survival and disease-free rates for each gene were illustrated. CONCLUSIONS: The present research suggests a panel signature of 24 gene biomarkers in diagnosing the PTC.
BACKGROUND: One of the well-differentiated types of thyroid cancer is papillary thyroid cancer (PTC), often developed by genetic mutations and radiation. METHODS: In this study, the public NCBI-GEO database was systematically searched. The eligible datasets were the targets for biomarker discovery associated with PI3K signaling pathway. RESULTS: Only two datasets were suitable and passed the inclusion criteria. The meta-analysis outcomes revealed eleven upregulation and thirteen downregulation genes differentially expressed between PTC and healthy tissues. Moreover, the outcomes for survival and disease-free rates for each gene were illustrated. CONCLUSIONS: The present research suggests a panel signature of 24 gene biomarkers in diagnosing the PTC.