Literature DB >> 340006

Indoprofen and naproxen in the treatment of rheumatoid arthritis: a clinical trial.

H Berry, L Fernandes, A K Clarke, E B Hamilton, J Davies, A J Dixon.   

Abstract

Thirty-six patients suffering from rheumatoid arthritis took part in a double-blind crossover trial, in which they received either indoprofen 800 mg/day, naproxen 500 mg/day, or a matching placebo. Indoprofen was shown to be significantly superior as an analgesic and in improving grip strength and the patients preferred it. Adverse effects were comparable, although indigestion was seen slightly more often during indoprofen treatment. Indoprofen is therefore at least as effective as existing anti-inflammatory drugs in rheumatoid arthritis and seems to be better tolerated.

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Year:  1978        PMID: 340006      PMCID: PMC1602704          DOI: 10.1136/bmj.1.6108.274

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  7 in total

1.  New analgesic-anti-inflammatory drugs. 1-Oxo-2-substituted isoindoline derivatives.

Authors:  G Nannini; P N Giraldi; G Molgora; G Biasoli; F Spinelli; W Logemann; E Dradi; G Zanni; A Buttinoni; R Tommasini
Journal:  Arzneimittelforschung       Date:  1973-08

2.  Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.

Authors:  D M Ritchie; J A Boyle; J M McInnes; M K Jasani; T G Dalakos; P Grieveson; W W Buchanan
Journal:  Q J Med       Date:  1968-07

3.  Fate of the analgesic and anti-inflammatory drug K 4277 after oral administration to man.

Authors:  L M Fuccella; G C Goldaniga; E Moro; V Tamassia; G P Tosolini; G Valzelli
Journal:  Eur J Clin Pharmacol       Date:  1973-12       Impact factor: 2.953

4.  Four new anti-inflammatory drugs: responses and variations.

Authors:  E C Huskisson; D L Woolf; H W Balme; J Scott; S Franklin
Journal:  Br Med J       Date:  1976-05-01

5.  Gastro-intestinal blood loss during administration of indoprofen, aspirin and ibuprofen.

Authors:  G B Porro; G Corvi; L M Fuccella; G C Goldaniga; G Valzelli
Journal:  J Int Med Res       Date:  1977       Impact factor: 1.671

6.  Indoprofen, a new analgesic and anti-inflammatory drug in cancer pain.

Authors:  V Ventafridda; G Martino; V Mandelli; A Emanueli
Journal:  Clin Pharmacol Ther       Date:  1975-03       Impact factor: 6.875

7.  Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin.

Authors:  E C Huskisson; J A Wojtulewski; H Berry; J Scott; F D Hart; H W Balme
Journal:  Br Med J       Date:  1974-02-02
  7 in total
  1 in total

Review 1.  Naproxen up to date: a review of its pharmacological properties and therapeutic efficacy and use in rheumatic diseases and pain states.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1979-10       Impact factor: 9.546

  1 in total

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