| Literature DB >> 34000374 |
Mayarling Francisca Troncoso1, Jafet Ortiz-Quintero2, Valeria Garrido-Moreno1, Fernanda Sanhueza-Olivares1, Alejandra Guerrero-Moncayo1, Mario Chiong1, Pablo F Castro3, Lorena García1, Luigi Gabrielli3, Ramón Corbalán3, Luis Garrido-Olivares4, Sergio Lavandero5.
Abstract
The vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically participates in the adhesion and transmigration of leukocytes to the interstitium during inflammation. VCAM-1 expression, together with soluble VCAM-1 (sVCAM-1) induced by the shedding of VCAM-1 by metalloproteinases, have been proposed as biomarkers in immunological diseases, cancer, autoimmune myocarditis, and as predictors of mortality and morbidity in patients with chronic heart failure (HF), endothelial injury in patients with coronary artery disease, and arrhythmias. This revision aims to discuss the role of sVCAM-1 as a biomarker to predict the occurrence, development, and preservation of atrial fibrillation (AF).Entities:
Keywords: Atrial fibrillation; Biomarker; VCAM-1; cardiovascular diseases; sVCAM-1
Year: 2021 PMID： 34000374 DOI： 10.1016/j.bbadis.2021.166170
Source DB: PubMed Journal: Biochim Biophys Acta Mol Basis Dis ISSN： 0925-4439 Impact factor: 5.187