Michael Gao1, Eswari Vilayur1,2, David Ferreira1,3, Ranjit Nanra1,2, Joan Hawkins4. 1. Department of Nephrology, John Hunter Hospital, Newcastle, Australia. 2. School of Medicine and Public Health, University of Newcastle, Newcastle, Australia. 3. School of Medicine, University of New South Wales, Sydney, Australia. 4. Department of Obstetrics and Gynaecology, John Hunter Hospital, Newcastle, Australia.
Abstract
AIM: To compare the performance of the Nanra and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating glomerular filtration rate in pregnancy against the 24 h urine creatinine clearance. METHODS: Pregnant women had 24 h urine collections with simultaneous serum creatinine levels. Measured 24 h urine creatinine clearance was compared to two equations: Nanra and CKD-EPI. Level of concordance was measured, with an a priori bias acceptance of ±15 ml/min/1.73 m2. RESULTS: A total of 53 synchronous urine and serum creatinine samples were analysed. The Nanra equation had a bias of -13.4 ml/min/1.73 m2 while the CKD-EPI equation had bias of 14.2 ml/min/1.73 m2. Both equations showed a high degree of proportional error and had poor agreement with 24 h urine creatinine clearance. CONCLUSIONS: None of the equations were shown to reliably measure the estimated glomerular filtration rate in pregnant women. A valid serum creatinine-based estimated glomerular filtration rate equation in pregnancy is yet to be established.
AIM: To compare the performance of the Nanra and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating glomerular filtration rate in pregnancy against the 24 h urine creatinine clearance. METHODS: Pregnant women had 24 h urine collections with simultaneous serum creatinine levels. Measured 24 h urine creatinine clearance was compared to two equations: Nanra and CKD-EPI. Level of concordance was measured, with an a priori bias acceptance of ±15 ml/min/1.73 m2. RESULTS: A total of 53 synchronous urine and serum creatinine samples were analysed. The Nanra equation had a bias of -13.4 ml/min/1.73 m2 while the CKD-EPI equation had bias of 14.2 ml/min/1.73 m2. Both equations showed a high degree of proportional error and had poor agreement with 24 h urine creatinine clearance. CONCLUSIONS: None of the equations were shown to reliably measure the estimated glomerular filtration rate in pregnant women. A valid serum creatinine-based estimated glomerular filtration rate equation in pregnancy is yet to be established.
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