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Literature DB >> 3399496

Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

Abstract

We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.

Entities: Chemical

Mesh：

Substances：

Year: 1988 PMID： 3399496 PMCID： PMC281754 DOI： 10.1073/pnas.85.15.5355

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

5 in total

Review 1. Binding energy, specificity, and enzymic catalysis: the circe effect.

Authors: W P Jencks
Journal: Adv Enzymol Relat Areas Mol Biol Date: 1975

2. Catalytic antibodies.

Authors: A Tramontano; K D Janda; R A Lerner
Journal: Science Date: 1986-12-19 Impact factor: 47.728

3. A stereospecific cyclization catalyzed by an antibody.

Authors: A D Napper; S J Benkovic; A Tramontano; R A Lerner
Journal: Science Date: 1987-08-28 Impact factor: 47.728

4. A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors.

Authors: P J Henderson
Journal: Biochem J Date: 1972-04 Impact factor: 3.857

5. Chemical reactivity at an antibody binding site elicited by mechanistic design of a synthetic antigen.

Authors: A Tramontano; K D Janda; R A Lerner
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

5 in total

7 in total

Review 1. New developments in enzymatic peptide synthesis.

Authors: C H Wong; K T Wang
Journal: Experientia Date: 1991-12-01

Review 2. Catalytic antibodies.

Authors: G M Blackburn; A S Kang; G A Kingsbury; D R Burton
Journal: Biochem J Date: 1989-09-01 Impact factor: 3.857

Catalysis of a stereospecific bimolecular amide synthesis by an antibody.

Review 1. Binding energy, specificity, and enzymic catalysis: the circe effect.

2. Catalytic antibodies.

3. A stereospecific cyclization catalyzed by an antibody.

4. A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors.

5. Chemical reactivity at an antibody binding site elicited by mechanistic design of a synthetic antigen.

Review 1. New developments in enzymatic peptide synthesis.

Review 2. Catalytic antibodies.

Review 3. Immune recognition, antigen design, and catalytic antibody production.

Review 4. Hapten design for the generation of catalytic antibodies.

Review 5. Dissection of an antibody-catalyzed reaction.

6. Aspects of antibody-catalyzed primary amide hydrolysis.

7. Antibody catalysis of peptide bond formation.