Literature DB >> 339941

Glial fibrillary acidic protein in tumours of the nervous system.

B Delpech, A Delpech, M N Vidard, N Girard, J Tayot, J C Clement, P Creissard.   

Abstract

Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA. Tumours with astrocytic differentiation potential (medulloblastoma) may contain GFA. Comparison of microscopic and GFA assays leads us to conclude that GFA concentration is proportional to the amount of malignant astrocytes in the tumour and inversely proportional to the necrotic area of a tumour. Normal tissue GFA and glioblastoma GFA were found to be immunologically identical.

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Year:  1978        PMID： 339941      PMCID： PMC2009497          DOI： 10.1038/bjc.1978.5

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  13 in total

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Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Differentiation of astrocytes in the cerebellar cortex and the pyramidal tracts of the newborn rat. An immunofluorescence study with antibodies to a protein specific to astrocytes.

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Journal:  Brain Res       Date:  1973-01-30       Impact factor: 3.252

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Authors:  B Delpech; A Delpech; J Clément; R Laumonier
Journal:  Int J Cancer       Date:  1972-03-15       Impact factor: 7.396

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Journal:  Immunochemistry       Date:  1969-01

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Journal:  C R Seances Soc Biol Fil       Date:  1973

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Journal:  Brain Res       Date:  1971-05-07       Impact factor: 3.252

7.  Presence of neurospecific antigen NSA 1 in fetal human astrocytes in long-term culture.

Authors:  R Maunoury; A Delpech; B Delpech; M N Vidard; C Vedrenne
Journal:  Brain Res       Date:  1976-08-13       Impact factor: 3.252

8.  [Immunochemical characterization of a neuro-specific, non species specific antigen. Quantitative study and histological localization in the rat].

Authors:  B Delpech; A Delpech
Journal:  Immunochemistry       Date:  1975-08

9.  Immunological study of the glial fibrillary acidic protein.

Authors:  C T Uyeda; L F Eng; A Bignami
Journal:  Brain Res       Date:  1972-02-11       Impact factor: 3.252

10.  Antigens in human glioblastomas and meningiomas: Search for tumour and onco-foetal antigens. Estimation of S-100 and GFA protein.

Authors:  L Dittmann; N H Axelsen; B Norgaard-Pedersen; E Bock
Journal:  Br J Cancer       Date:  1977-02       Impact factor: 7.640
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  16 in total

1.  DNA content and marker expression in human glioma explants.

Authors:  R D Davenport; P E McKeever
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

2.  Medulloblastomas in childhood: histological factors influencing patients' outcome.

Authors:  K Taomoto; T Tomita; A J Raimondi; J E Leestma
Journal:  Childs Nerv Syst       Date:  1987       Impact factor: 1.475

3.  Computerized classification of gliomas by automated microscope picture analysis (AMPA).

Authors:  H Martin; K Voss
Journal:  Acta Neuropathol       Date:  1982       Impact factor: 17.088

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Authors:  P E McKeever; S Laverson; P L Kornblith; R Howard; E A Quindlen; B H Smith; B M Chronwall
Journal:  Acta Neuropathol       Date:  1982       Impact factor: 17.088

Review 5.  Immunobiologic aspects of the brain and human gliomas. A review.

Authors:  C J Wikstrand; D D Bigner
Journal:  Am J Pathol       Date:  1980-02       Impact factor: 4.307

6.  Immunohistochemical study of glial fibrillary acidic protein in avian sarcoma virus-induced gliomas in dogs.

Authors:  R H Britt; B E Lyons; L F Eng; S H Bigner; D D Bigner
Journal:  J Neurooncol       Date:  1985       Impact factor: 4.130

7.  Glial fibrillary acidic protein in medulloblastomas and other embryonic CNS tumours of children.

Authors:  E Schindler; F Gullotta
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1983

8.  Products of cells cultured from gliomas. VI. Immunofluorescent, morphometric, and ultrastructural characterization of two different cell types growing from explants of human gliomas.

Authors:  P E McKeever; B H Smith; J A Taren; R L Wahl; P L Kornblith; B M Chronwall
Journal:  Am J Pathol       Date:  1987-05       Impact factor: 4.307

9.  Medulloblastoma: histological evaluation and prognosis. A clinical, immunohistochemical and electron microscopic study.

Authors:  J Szymas; W Biczysko; P Gabryel; S Morkowski
Journal:  Childs Nerv Syst       Date:  1987       Impact factor: 1.475

10.  Glial fibrillary acidic protein in medulloblastoma.

Authors:  H Mannoji; I Takeshita; M Fukui; M Ohta; K Kitamura
Journal:  Acta Neuropathol       Date:  1981       Impact factor: 17.088
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