Meng Lu1, Qin Xueying1,2, Peng Hexiang1, Gao Wenjing1, Sara Hägg2, Cao Weihua1, Li Chunxiao1, Yu Canqing1, Lv Jun1, Pang Zengchang3, Cong Liming4, Wang Hua5, Wu Xianping6, Wang Yunzhang2, Li Liming1. 1. Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China. 2. Department of Medical Epidemiology & Biostatistics, Karolinska Institute, 171 76 Stockholm, Sweden. 3. Qingdao Center for Disease Control & Prevention, Qingdao 266033, PR China. 4. Zhejiang Center for Disease Control & Prevention, Hangzhou 310051, PR China. 5. Jiangsu Center for Disease Control & Prevention, Nanjing 210009, PR China. 6. Sichuan Center for Disease Control & Prevention, Chengdu 610041, PR China.
Abstract
Aim: Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and disease, but limited number of positive CpG sites repeatedly replicated. Materials & methods: In total, 57 monozygotic (MZ) twin pairs discordant for alcohol drinking from the Chinese National Twin Registry and 158 MZ and dizygotic twin pairs in the Swedish Adoption/Twin Study of Aging were evaluated. DNA methylation was detected using the Infinium HumanMethylation450 BeadChip. Results: Among candidate CpG sites, cg07326074 was significantly correlated with drinking after adjusting for covariates in MZ twins in both datasets but not in the entire sample or dizygotic twins. Conclusion: The hypermethylation of cg07326074, located in the tumor-promoting gene C16orf59, was associated with alcohol consumption.
Aim: Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and disease, but limited number of positive CpG sites repeatedly replicated. Materials & methods: In total, 57 monozygotic (MZ) twin pairs discordant for alcohol drinking from the Chinese National Twin Registry and 158 MZ and dizygotic twin pairs in the Swedish Adoption/Twin Study of Aging were evaluated. DNA methylation was detected using the Infinium HumanMethylation450 BeadChip. Results: Among candidate CpG sites, cg07326074 was significantly correlated with drinking after adjusting for covariates in MZ twins in both datasets but not in the entire sample or dizygotic twins. Conclusion: The hypermethylation of cg07326074, located in the tumor-promoting gene C16orf59, was associated with alcohol consumption.
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