| Literature DB >> 33992742 |
Aarti Sharma1, Sidharth Mehan2.
Abstract
PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism for mammalian enzyme-related receptors in transducing signals or biological processes such as cell development, differentiation, cell survival, protein synthesis, and metabolism. Upregulation of the PI3K-AKT/mTOR signaling pathway involves many human brain abnormalities, including autism and other neurological dysfunctions. Autism is a neurodevelopmental disorder associated with behavior and psychiatric illness. This research-based review discusses the functional relationship between the neuropathogenic factors associated with PI3K-AKT/mTOR signaling pathway. Ultimately causes autism-like conditions associated with genetic alterations, neuronal apoptosis, mitochondrial dysfunction, and neuroinflammation. Therefore, inhibition of the PI3K-AKT/mTOR signaling pathway may have an effective therapeutic value for autism treatment. The current review also summarizes the involvement of PI3K-AKT/mTOR signaling pathway inhibitors in the treatment of autism and other neurodegenerative disorders.Entities:
Keywords: Apoptosis; Autism; Genetic dysfunction; PI3K-AKT; Serotonergic degeneration; mTOR
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Year: 2021 PMID： 33992742 DOI： 10.1016/j.neuint.2021.105067
Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921