Psychological factors affecting COVID-19 vaccine hesitancy.

BACKGROUND: Vaccine hesitancy is an important public health problem. AIMS: Identifying and understanding COVID-19 vaccine hesitancy may aid future public health messaging. This study, in which we planned to study the determinants of COVID-19 vaccine hesitancy, aims to reveal the relationship between "intolerance of uncertainty," "belief in conspiracy theories," and "COVID-19 phobia" with vaccine hesitancy.
METHODS: This is a cross-sectional study conducted during a COVID-19 outbreak. Participants were reached via various social media platforms and e-mailing lists for convenience. Data were collected with an online survey using SurveyMonkey application. "Intolerance of Uncertainty Scale (IUS-12)," "Conspiracy Mentality Scale (CMS)," and "COVID-19 Phobia Scale" were applied to 488 participants. Statistical significance level was considered p < 0.05.
RESULTS: Four hundred eighty-eight people between the ages of 18 and 65 participated. Twenty-one participants were excluded from the analysis due to random marking and unreasonable filling times (< 10 min). In this way, analyzes were made with 467 people. We found a positive correlation between the belief in conspiracy theories and vaccine hesitancy (p < 0.05). And also found that individuals with low fear of COVID-19 would hesitate about vaccination (p < 0.05).
CONCLUSIONS: Vaccine hesitancy is an important public health problem, and it puts public health at risk, especially during the epidemic period we live in. Therefore, it is important to understand the psychological factors involved in vaccine hesitancy. It would be useful to look for ways to spread accurate information about the vaccine in a healthier way in this case.

Introduction

Severe acute respiratory syndrome coronavirus disease 2019 (COVID-19) pandemic caused by coronavirus 2 (SARS-CoV-2) was first detected in Wuhan, China, in December 2019. It spread worldwide within 1 month of the emergence of the novel coronavirus. The World Health Organization (WHO) declared COVID-19 a pandemic worldwide on 11 March 2020 [1]. Physical distance and quarantine measures have been put in place to slow the spread of the virus around the world, protect the community, and manage healthcare demand and delivery since there is no effective treatment or vaccine [2]. However, the need for an approved vaccine has become indisputable to protect society from this virus and save the economy from ongoing interruptions and damage.

The concept of “vaccine hesitancy” is seen by the World Health Organization (WHO) as “one of the top ten threats to global health.” It is wondered whether the COVID-19 outbreak, which can be defined as a global and emergency situation, will solve the vaccine rejection problem that is worrying for public health for the last few decades [3]. Most of the current literature on vaccine hesitancy and resistance focuses on the clear causes individuals exhibit against a particular vaccine or vaccination programs in general [4]. Identifying psychological processes that distinguish vaccine-hesitant and resistant individuals from vaccine-sensitive individuals will be a guiding approach [5]. This approach may also provide the opportunity to adapt public health messages in accordance with the psychological tendencies of these individuals [6]. To date, many psychological structures have been investigated in relation to vaccine hesitancy. For example, altruistic beliefs [7]; personality traits neuroticism and conscientiousness [8]; conspiracy, religious, and paranoid beliefs [9]; distrust of authorized members of society such as government officials, scientists, and healthcare professionals have been associated with negative attitudes towards vaccines [12].

Vaccine hesitancies tend to increase overall even though it varies between countries [9]. It is important to reveal the determinants of vaccine hesitancy considering the increase in conspiracy theories about COVID-19 [10, 11]. Determining, understanding, and addressing vaccine acceptance, vaccine hesitancy, and vaccine resistance for COVID-19 are important steps to ensure the rapid and necessary use of a final vaccine [4, 12].

This study, in which we planned to study the determinants of COVID-19 vaccine hesitancy, aims to reveal the relationship between “intolerance of uncertainty,” “belief in conspiracy theories,” and “COVID-19 phobia” with vaccine hesitancy. We hypothesized that individuals who believe in conspiracy theories and have a low tolerance to uncertainty would have increased coronavirus vaccine hesitancy/rejection considering that vaccine hesitancy determinants should be revealed because vaccine hesitancy/rejection is an obstacle to controlling outbreaks. Individuals with low fear of COVID-19 will hesitate about vaccination. This study aims to examine the extent to which COVID-19 phobia, belief in conspiracy theories, and intolerance of uncertainty are decisive in vaccine hesitancy.

It would be useful to identify distinguishing psychological factors of individuals who are hesitant and resistant to the vaccine. In this way, the issue of “vaccine rejection” as a public health problem can be further clarified and actions for public health can focus on more targets. The problems in front of vaccination, which is the most important weapon in the fight against the pandemic, can be overcome.

Methods

Participants and procedure

This is a cross-sectional study conducted during a COVID-19 outbreak. Participants were reached via various social media platforms and e-mailing lists for convenience. Surveys were administered through “SurveyMonkey,” a platform that allows them to be distributed and analyzed on the web. The demographic characteristics of the respondents include whether they have been infected with COVID-19 before, whether they are ready to get the COVID-19 vaccine, and the “Intolerance of Uncertainty Scale (IUS-12),” “Conspiracy Mentality Scale (CMS),” and “COVID-19 Phobia Scale.”

Four hundred eighty-eight people between the ages of 18 and 65 participated between March and April 2021. Twenty-one participants were excluded from the analysis due to random marking and unreasonable filling times (< 10 min). In this way, analyses were made with 467 people. All participants were informed about the study, and the participants were included in the study voluntarily. Ethics committee approval was received from Ordu University.

Scales

Intolerance of uncertainty scale

It was observed that 12 items were collected in two subscales (prospective anxiety and debilitating anxiety) consistent with the original form in the confirmatory factor analysis applied for the construct validity of the scale (χ2 = 147.20, SD = 48, RMSEA = 0.073, CFI = 0.95, IFI = 0.95, GFI = 0.94, SRMR = 0.046). Factor loads of the scale were ranked between 0.55 and 0.87, Cronbach’s alpha consistency coefficient was found to be 0.88 for the whole scale, 0.84 for the prospective anxiety subscale, and 0.77 for the debilitating anxiety subscale. The test–retest correlation coefficient was found to be 0.74; it was also seen that the adjusted item-total correlations of the scale were ranked between 0.42 and 0.68 [13].

Conspiracy mentality scale

Bruder and Manfred (2009) collected data from Germany, Britain, and Turkey with a conspiracy theory scale consisting of 38 items related to conspiracy theories [14]. Bruder et al. (2013) used this data to define 5 items of the scale consisting of 38 items as Conspiracy Mentality Scale (CMS) and the remaining 33 items as items that measure believing in specific conspiracy theories [15]. Participants were asked to indicate how much they agreed with the items given in the scales on 11-point Likert type scales (0% = absolutely no, 100% = absolutely yes), and the 5 items mentioned in this study, which was previously conducted, were grouped separately. The obtained Conspiracy Mentality Scale (CMS) was found to be 0.72 for α reliability for the Turkish version. The remaining 33 items measure believing in specific conspiracy theories generally [16].

COVID-19 phobia scale

The COVID-19 Phobia Scale is a scale that can be used to measure feelings such as fear, anxiety, and related behavior changes during the COVID-19 pandemic. Item-total item analyses were performed with 1243 subjects in the permeability and reliability study. It consists of a total of 4 subscales and 22 items: worry, mood, reassurance seeking/precaution, and avoidance subscales. The Cronbach’s alpha coefficient, which shows internal consistency, was measured as 0.84, and the internal consistency coefficients of the subscales ranged from 0.60 to 0.91 [17].

Vaccine conspiracy beliefs scale

In addition, an additional questionnaire was created by the study team from social media accounts using the 5 most popular conspiracy theories related to vaccines in Turkey in order to have a parallel quality to the Conspiracy Mentality Scale.

Statistical analysis

The research data was uploaded and evaluated on a computer environment via “SPSS (Statistical Package for Social Sciences) for Windows 15.0 (SPSS Inc., Chicago, IL)” software. Descriptive statistics were presented as mean ± standard deviation (minimum–maximum), frequency distribution, and percentage. The Pearson’s chi-square test was used to evaluate categorical variables. The suitability of the variables for normal distribution was examined using visual (histogram and probability graphs) and analytical methods (Kolmogorov–Smirnov Test/Shapiro–Wilk Test). The Kruskal Wallis Test was used as the statistical method in the statistical significance between the four independent groups for the variables found not to comply with the normal distribution. Bonferroni correction was applied in post hoc binary comparisons of the source of the difference when a significant difference was detected. The relationship between the variables was evaluated by the Spearman’s correlation test. The correlation coefficient was considered “weak” between 0 and 0.30, “moderate” between 0.31 and 0.70, and “strong” between 0.71 and 1.00. Statistical significance level was considered p < 0.05.

Results

A total of 467 individuals over the age of 18 who agreed to participate and who could give complete answers to the questions in the data collection form were examined within the study’s scope. Some descriptive characteristics of the individuals examined are given in Table 1.

Table 1

Some descriptive characteristics of the participants

	(n = 467)
Age (years), mean ± SD (min–max)	35.8 ± 9.1 (18–67)
Gender, n (%)
Male	206 (44.1)
Female	261 (55.9)
Marital status, n (%)
Married	295 (63.2)
Single	161 (34.5)
Other	11 (2.4)
Child status, n (%)
Yes	244 (52.2)
No	223 (47.8)
Number of children of those with children (n = 244), mean ± SD (min–max)	1.7 ± 0.8 (1–4)
Profession, n (%)
Physician	180 (38.5)
Teacher	46 (9.9)
Assistant healthcare personnel	44 (9.4)
Pharmaceutical representative	26 (5.6)
Housewife	20 (4.3)
Engineer	19 (4.1)
School student	14 (3.0)
Dentist	13 (2.8)
Faculty member	12 (2.6)
Not working	11 (2.4)
Other	82 (17.6)
Previous COVID-19 experience
Yes	80 (17.1)
No	387 (82.9)
Treatments administered to COVID-19 patients (n = 80)
Outpatient treatment	75 (93.8)
Inpatient treatment in hospital	3 (3.8)
Inpatient treatment in ICU	2 (2.5)
COVID-19 experience of a first-degree relative
Yes	173 (37.0)
No	294 (63.0)
Death of a first-degree relative or close friend due to COVID-19
Yes	63 (13.5)
No	404 (86.5)

n number of individuals, % percent, mean mean, SD standard deviation

The participants mean age included in the study was 35.8 ± 9.1 (min 18–max 67) years, and 55.9% (n = 261) were female. 63.2% (n = 295) of respondents were married, 34.5% (n = 161) were single, and the remaining 2.4% (n = 119) were divorced, widowed, or separated. 52.2% (n = 244) of the participants had children. The mean number of children of the participants with children was 1.7 ± 0.8 (min 1–max 4). Physicians were in the first place with 38.5% (n = 180), followed by teachers with 9.9% (n = 46), and assistant healthcare personnel with 9.4% (n = 44) considering the professions of the participants. The least identified professional groups were engineering with 4.1% (n = 19), dentistry with 2.8% (n = 13), and faculty membership with 2.6% (n = 12) (Table 1).

Some characteristics of the participants related to COVID-19 are shown in Table 1.

17.1% (n = 80) of participants included in the study had previously experienced COVID-19. Of these 80 participants, 93.8% (n = 75) received outpatient treatment, 3.8% (n = 3) received inpatient treatment, and the remaining 2.5% (n = 2) received inpatient treatment in intensive care unit (ICU). 13.5% (n = 63) had first-degree relatives or close friends dying from COVID-19 whereas 37.0% (n = 173) of the participants had first-degree relatives suffering from COVID-19 (Table 1).

Attitudes of participants towards the COVID-19 vaccine are presented in Table 2. 44.1% (n = 206) of the respondents examined stated that they trusted the positive effects of the vaccine and wanted to get vaccinated, 40.9% (n = 191) stated that they were undecided about the positive effects of the vaccine but wanted to get vaccinated, 8.8% (n = 41) stated that they were undecided about the positive effects of the vaccine and did not want to get vaccinated, and 6.2% (n = 29) stated that they thought that the vaccine would have negative effects/would be ineffective and did not want to get vaccinated (Table 2).

Table 2

Attitudes of participants towards COVID-19 vaccine

(n = 467)	n (%)
Attitude towards COVID-19 vaccine
Trusts the positive effects of the vaccine and wants to get vaccinated	206 (44.1)
Unsure about the positive effects of the vaccine but wants to get vaccinated	191 (40.9)
Unsure about the positive effects of the vaccine and does not want to get vaccinated	41 (8.8)
Thinks the vaccine will have negative effects/will be ineffective and does not want to get vaccinated	29 (6.2)

n number of individuals, % percent

Scores from four different scales applied to participants are presented in Table 3.

Table 3

Scores of the scales applied to participants

(n = 467)	Mean ± SD (min–max)
COVID-19 Phobia Scale
Anxiety	33.5 ± 8.5 (10–50)
Reassurance seeking/precaution	24.6 ± 4.9 (7–35)
Mood	8.3 ± 2.9 (3–15)
Avoidance	8.2 ± 1.7 (2–10)
Total	74.5 ± 15.5 (22–110)
Intolerance of Uncertainty Scale 12 (IUS-12)
Prospective anxiety	23.2 ± 5.4 (7–35)
Debilitating anxiety	15.2 ± 5.0 (5–25)
Total	38.4 ± 9.7 (12–60)
Conspiracy Mentality Scale (CMS)	34.0 ± 8.8 (0–50)
Vaccine Conspiracy Beliefs Scale (VCBS)	21.2 ± 12.6 (0–50)

n number of individuals, mean mean, SD standard deviation, IUS Intolerance of Uncertainty Scale, CMS Conspiracy Mentality Scale, VCBS Vaccine Conspiracy Beliefs Scale

The mean total score of the participants examined within the scope of the study from the COVID-19 Phobia Scale was 74.5 ± 15.5 (min 22–max 110), the mean score of the “worry” subscale was 33.5 ± 8.5 (min 10–max 50), the mean score of the “reassurance seeking/precaution” subscale was 24.6 ± 4.9 (min 7–max 35), the mean score of the “mood” subscale was 8.3 ± 2.9 (min 3–max 15), and the mean score of the “avoidance” subscale was 8.2 ± 1.7 (min 2–max 10) (Table 3).

The mean total score of the Intolerance of Uncertainty Scale (IUS-12) was 38.4 ± 9.7 (min 12-max 60), the mean score of the “prospective anxiety” subscale was 23.2 ± 5.4 (min 7–max 35), and the mean score of the “debilitating anxiety” subscale was 15.2 ± 5.0 (min 5–max 25) (Table 3).

The mean score of the Conspiracy Mentality Scale (CMS) applied to the participants was 34.0 ± 8.8 (min 0–max 50) whereas the mean Vaccine Conspiracy Beliefs Scale (VCBS) score was 21.2 ± 12.6 (min 0–max 50) (Table 3).

The distribution of participants’ descriptive characteristics according to their attitudes towards the COVID-19 vaccine is presented in Table 4. There was a statistically significant difference between the participants’ attitudes towards the COVID-19 vaccine in terms of age and gender (p = 0.003; p = 0.002, respectively). Post hoc binary comparisons showed that the significant difference in age was between “those who trusted the positive effects of the vaccine and wanted to get vaccinated” and “those who thought the vaccine would have negative effects/would be ineffective and did not want to get vaccinated.” The age of those who thought the vaccine would have negative effects/would be ineffective and did not want to get vaccinated was significantly lower compared to those who trusted the positive effects of the vaccine and wanted to get vaccinated. In addition, the percentage of men who trusted the positive effects of the vaccine and wanted to get vaccinated was significantly higher compared to the other attitude groups (Table 4). On the other hand, there were no statistically significant differences between participants’ attitudes towards the COVID-19 vaccine in terms of marital status, child status, and the number of children of those with children (p > 0.05) (Table 4).

Table 4

Distribution of some descriptive characteristics of participants according to their attitudes towards COVID-19 vaccine

	Attitude towards COVID-19 vaccine				p
	Group I (n = 206)	Group II (n = 191)	Group III (n = 41)	Group IV (n = 29)
Age (years), mean ± SD (min–max)	36.9 ± 8.6 (22–65)	35.8 ± 9.3 (19–67)	32.5 ± 9.5 (18–61)	32.0 ± 8.0 (21–47)a	0.003*
Gender, n (%)
Male	110 (53.4)	65 (34.0)	18 (43.9)	13 (44.8)	0.002*
Female	96 (46.6)	126 (66.0)	23 (56.1)	16 (55.2)
Marital status, n (%)
Married	137 (66.5)	124 (64.9)	21 (51.2)	13 (44.8)	0.224
Single	65 (31.6)	62 (32.5)	19 (46.3)	15 (51.7)
Other	4 (1.9)	5 (2.6)	1 (2.4)	1 (3.4)
Child presence, n (%)	117 (56.8)	100 (52.4)	16 (39.0)	11 (37.9)	0.073
Number of children of those with children, mean ± SD (min–max)	1.7 ± 0.8 (1–4)	1.7 ± 0.7 (1.4)	2.2 ± 1.1 (1–4)	1.7 ± 0.6 (1–3)	0.337
Previous COVID-19 experience	36 (17.5)	28 (14.7)	8 (19.5)	8 (27.6)	0.357
Treatments administered to COVID-19 patients
Outpatient treatment	34 (94.4)	27 (96.4)	6 (75.0)	8 (100)	0.127
Inpatient treatment	2 (5.6)	1 (3.6)	2 (25.0)	0
COVID-19 experience of a first degree relative	76 (36.9)	71 (37.2)	16 (39.0)	10 (34.5)	0.985
Death of a first degree relative or close friend due to COVID-19	18 (8.7)	30 (15.7)	7 (17.1)	8 (27.6)	0.017*

n number of individuals, % column percentage, mean mean, SD standard deviation, Group I trusts the positive effects of the vaccine and wants to get vaccinated, Group II unsure about the positive effects of the vaccine but wants to get vaccinated, Group III unsure about the positive effects of the vaccine and does not want to get vaccinated, Group IV thinks the vaccine will have negative effects/will be ineffective and does not want to get vaccinated

*p < 0.05

aPost hoc paired comparison revealed a significant difference with the “group I” group

The distribution of some characteristics of participants related to COVID-19 according to their attitudes towards the COVID-19 vaccine is presented in Table 4. There was a statistically significant difference between participants’ attitudes towards the COVID-19 vaccine in terms of a death of a first-degree relative or close friend due to COVID-19 (p = 0.017). Among those who thought the vaccine would have negative effects/would be ineffective and did not want to get vaccinated, the percentage of those with a first-degree relative or close friend that died due to COVID-19 was significantly higher compared to the other attitude groups (Table 4). On the other hand, there were no statistically significant differences between participants’ attitudes towards the COVID-19 vaccine in terms of previous COVID-19 experience, types of treatment administered to COVID-19 patients, and COVID-19 experience of a first-degree relative (p > 0.05) (Table 4).

The distribution of scale scores applied among participants’ attitudes towards the COVID-19 vaccine is presented in Table 5. There was a statistically significant difference between participants’ attitudes towards the COVID-19 vaccine in terms of the COVID-19 Phobia Scale total score (p = 0.002). Post hoc binary comparisons showed that the significant difference was between those who were undecided about the positive effects of the vaccine but wanted to get vaccinated (group II) and those who were undecided about the positive effects of the vaccine and did not want to get vaccinated (group III) and those who thought that the vaccine would have negative effects/would have negative effects and did not want to get vaccinated (group IV). The total COVID-19 Phobia Scale score of those who were undecided about the positive effects of the vaccine but wanted to get vaccinated (group II) was significantly higher compared to those who were undecided about the positive effects of the vaccine and did not want to get vaccinated (group III) and those who thought the vaccine would have negative effects/would be ineffective and did not want to get vaccinated (group IV) (Table 5).

Table 5

Distribution of scores of scales applied among participants’ attitudes towards COVID-19 vaccine

	Attitude towards COVID-19 Vaccine						p
	Group-I (n=206)	Group-II (n=191)		Group-III (n=41)	Group-IV (n=29)
COVID-19 Phobia Scale
Anxiety	33.3±8.3 (10-50)	34.9±7.9 (12-50)		30.3±10.1 (10-49)		29.9±9.8 (10-47)	0.007*
Reassurance seeking	24.5±4.6 (7-35)	25.5±4.4 (10-35)		22.8±5.7 (10-33)		21.0±6.6 (7-35)	<0.001*
Mood	8.1±2.8 (3-15)	8.6±2.9 (3-15)		8.0±3.1 (3-14)		7.7±3.4 (3-14)	0.208
Avoidance	8.2±1.6 (2-10)	8.3±1.6 (2-10)		8.2±1.6 (4-10)		7.2±2.2 (2-10)	0.058
Total	74.2±14.7 (22-110)	77.3±14.1 (34-108)		69.4±18.5 (35-104)		65.8±20.0 (22-98)	0.002*
IUS-12
Prospective anxiety	22.7±5.6 (7-35)	23.8±5.1 (8-35)	22.9±5.0 (11-33)			22.8±6.2 (7-35)	0.361
Debilitating anxiety	14.8±4.8 (5-25)	15.8±5.0 (5-25)	15.1±5.4 (5-25)			14.9±5.3 (5-22)	0.231
Total	37.4±9.8 (12-60)	39.6±9.4 (14-60)	38.0±9.5 (18-56)			37.7±10.6 (12-56)	0.229
CMS	31.8±8.7 (0-50)	35.3±7.9 (9-50)	37.6±9.2 (13-50)			36.8±10.3 (9-50)	<0.001*
VCBS	15.5±11.2 (0-50)	24.1±11.0 (0-50)	27.4±11.5 (0-50)			34.4±12.6 (0-50)	<0.001*

Variables were presented as “mean ± standard deviation (minimum–maximum)”

n number of individuals, IUS Intolerance of Uncertainty Scale, CMS Conspiracy mentality scale, VCBS Vaccine Conspiracy Beliefs Scale, Group I trusts the positive effects of the vaccine and wants to get vaccinated, Group II unsure about the positive effects of the vaccine but wants to get vaccinated, Group III unsure about the positive effects of the vaccine and does not want to get vaccinated, Group IV thinks the vaccine will have negative effects/will be ineffective and does not want to get vaccinated

*p < 0.05

There was a statistically significant difference between participants’ attitudes towards the COVID-19 vaccine in terms of the COVID-19 Phobia Scale “anxiety” subscale score (p = 0.007). Post hoc binary comparisons showed that the significant difference was between those who were undecided about the positive effects of the vaccine but wanted to get vaccinated (group II) and those who were undecided about the positive effects of the vaccine and did not want to get vaccinated (group III). The COVID-19 Phobia Scale “anxiety” subscale score of those who were undecided about the positive effects of the vaccine but wanted to get vaccinated (group II) was significantly higher compared to those who were undecided about the positive effects of the vaccine and did not want to get vaccinated (group III) (Table 5).

There was a statistically significant difference between participants’ attitudes towards the COVID-19 vaccine in terms of the COVID-19 Phobia Scale “reassurance seeking” subscale score (p < 0.001). Post hoc binary comparisons showed that the signifivaccinated (group II). The COVID-19 phobia “reassurance seeking” subscale score of those who thought the vaccine would have negative effects/would be ineffective and did not want to get vaccinated (group IV) was significantly lower compared to those who trusted the positive effects of the vaccine and wanted to get vaccinated (group I) and those who were undecided about the poscant difference was between those who thought the vaccine would have negative effects/would have negative effects and did not want to get vaccinated (group IV) and those who trusted the positive effects of the vaccine and wanted to get vaccinated (group I) and those who were undecided about the positive effects of the vaccine and wanted to get vaccinated (group II) and those who were undecided about the positive effects of the vaccine and did not want to get vaccinated (group III) and those who were undecided about the negative effects of the vaccine but wanted to get itive effects of the vaccine and wanted to get vaccinated (group II). In addition, the COVID-19 phobia “reassurance seeking” subscale score of those who were undecided about the positive effects of the vaccine and did not want to get vaccinated (group III) was significantly lower compared to those who were undecided about the positive effects of the vaccine but wanted to get vaccinated (group II) (Table 5).

On the other hand, there were no statistically significant differences between participants’ attitudes towards the COVID-19 vaccine in terms of COVID-19 phobia “mood” and “avoidance” subscale scores (p > 0.05) (Table 5).

There was a statistically significant difference between participants’ attitudes towards the COVID-19 vaccine in terms of CMS and VCBS scores (p < 0.001 for both). Post hoc binary comparisons showed that the significant differences were caused by those who trusted the positive effects of the vaccine and wanted to get vaccinated (group I). The CMS and VCBS scores of those who trusted the positive effects of the vaccine and wanted to get vaccinated (group I) were significantly lower compared to those who exhibited other attitudes (Table 5).

There were no statistically significant differences between participants’ attitudes towards the COVID-19 vaccine in terms of IUS-12 total score and “prospective anxiety” and “debilitating anxiety” subscale scores (p > 0.05) (Table 5).

The relationship between the scales applied to the participants included in the study is shown in Table 6.

Table 6

The relationship between the scales applied to the participants

(n=467)	Age	IUS-12			CMS	VCBS
		Prospective Anxiety	Debilitating Anxiety	Total
COVID-19 PHOBIA
Anxiety	0.038	0.384**	0.370**	0.404**	0.150**	0.173**
Reassurance Seeking	0.139**	0.316**	0.299**	0.331**	0.137**	0.208**
Mood	–0.007	0.375**	0.345**	0.387**	0.111*	0.113*
Avoidance	0.124**	0.306**	0.267**	0.309**	0.141**	0.027
Total	0.072	0.421**	0.405**	0.444**	0.166**	0.188**
IUS-12
Prospective Anxiety	–0.032	1.000	0.717**	0.923**	0.238**	0.203**
Debilitating Anxiety	–0.057	0.717**	1.000	0.925**	0.212**	0.255**
Total	–0.047	0.923**	0.925**	1.000	0.242**	0.244**
CMS	–0.028	0.238**	0.212**	0.242**	1.000	0.465**
VCBS	0.044	0.203**	0.255**	0.244**	0.465**	1.000

Variables are presented with Spearman’s correlation coefficient

n number of individuals, IUS Intolerance of Uncertainty Scale, CMS Conspiracy Mentality Scale, VCBS Vaccine Conspiracy Beliefs Scale

*p < 0.05; **p < 0.01

There was a positive, moderate, and weak statistically significant correlation between participants’ total COVID-19 Phobia Scale score and IUS-12 total score (r = 0.44), prospective anxiety (r = 0.42), and debilitating anxiety (r = 0.40) subscale scores, and between COVID-19 Phobia Scale total score and CMS (r = 0.17) and VCBS (r = 0.19) scores (p < 0.05) (Table 6).

There was a positive and weak statistically significant correlation between the participants’ total IUS-12 score and CMS (r = 0.24) and VCBS (r = 0.24) scores (p < 0.05) (Table 6).

A positive, moderate, and statistically significant relationship was found between the CMS score and VCBS score of the participants (r = 0.46; p < 0.05) (Table 6).

While a positive, weak, statistically significant relationship was found between the age of the participants examined within the scope of the study and the COVID-19 Phobia Scale “reassurance seeking (r = 0.14)” and “avoidance (r = 0.12)” subscale scores, no statistically significant relationship was found between the age of the participants and all other scale and subscale scores (p > 0.05) (Table 6).

Discussion

Two of our initial three hypotheses were confirmed according to the results of our study. In other words, we could not confirm the hypothesis that individuals who have a low tolerance to uncertainty will have increased coronavirus vaccine hesitancy/rejection. We found a positive correlation between the belief in conspiracy theories, which is our second hypothesis, and vaccine hesitancy. Our third hypothesis confirmed that individuals with low fear of COVID-19 would hesitate about vaccination.

One of the most striking points of our results was that 15% of respondents had a negative attitude towards vaccines. 44.1% stated that they trusted the vaccines’ effects and would get vaccinated, and 6.2% stated that the vaccine would have negative effects or would be ineffective or would not get vaccinated. Three percent of the participants in Turkey and the UK rejected the vaccine, 31% in Turkey, and 14% in the UK stated that they were undecided about getting vaccinated in another study conducted with 5024 people in the two countries [18]. These rates appear as a negative scenario about the process of vaccine administration, which appears to be the only way out of the pandemic in the social sense. We found that women had more negative attitudes towards vaccines when evaluated in terms of gender. The negative attitudes towards vaccines in women were also consistent with a number of studies in the literature [18-21]. This may be related to the mortality rates of the disease in the male gender [21]. In addition, women are more likely to make health-related decisions for their children, as well as for themselves, so they may be investigating further health-related information and may be more likely to be exposed to inaccurate information [22]. Increased information search can be an important factor given the information pollution that courageously spreads through social media. It was seen that anti-vaccine individuals shared more misleading claims on social media, and vaccine advocates were not prone to less reliable claims in a study evaluating 2000 Twitter accounts related to vaccine discourse [23]. It was shown in the same study that they also tweeted about conservative politics and conspiracy theories in their anti-vaccine accounts. The majority of social media users in Turkey are young people. This information is useful in explaining that the age of the “completely anti-vaccine” group, which is one of our study results, is significantly younger. It is consistent with the knowledge of young age and negative attitudes towards vaccines in the literature [24].

It was reported that 13.9% of participants would not get vaccinated or had low intentions about getting vaccinated in a previous study conducted with 735 university students [25]. No difference was found between the students studying in the departments related to the healthcare industry and those studying in other departments in terms of vaccine attitude in this study. Interpreting vaccine attitudes only through health information may make it difficult to understand the problem in this sense. Understanding whether there is a difference in these people’s access to information or in distinguishing the accurate information will be helpful in understanding vaccine attitudes. The relationship between anti-vaccine individuals and conspiracy theories can be enlightening in this respect.

The group, which was “completely anti-vaccine,” received lower scores on the COVID-19 Phobia Scale when we evaluated the results of our study on the scales. It may be thought that these people are less worried about COVID-19 compared to others because they underestimate the possible negative effects of COVID-19 and think it is an “exaggerated scenario” related to politics or the media. Previous studies have reported that belief in the natural origin of coronavirus is a factor that increases vaccine acceptance [18]. Believing that the virus is an artificial product may lead to underestimating pandemic situations and may therefore cause a negative attitude towards vaccines.

Anxiety and psychological processes associated with the pandemic may affect health behaviors and search for treatment [26, 27]. It can also be said that COVID-19 causes an emotionally burdensome process. This burdensome process and anti-vaccine discourses that emerge due to their nature may increase uncertainty and confusion [28]. Previous studies have reported that worries about vaccine safety, side effects, and rapid development may be associated with negative vaccination attitudes [29]. Negative emotions have been reported to be associated with vaccine risk perceptions and vaccine attitudes [30]. It will be important to address emotional processes and provide accurate and safe information to overcome negative attitudes towards vaccines [30]. Previous studies have indicated that the biggest worry about vaccines may be related to the quality control and side effect profiles of a COVID-19 vaccine [21]. Uncertainties about the vaccine and possible conspiracy theories can be expected to affect the vaccine administration in this sense adversely. Vaccine hesitancy has also been associated with conspiracy, paranoia, and religious beliefs [31-33]. In addition, distrust towards authorized persons was evaluated related to vaccine rejection [34-36].

The Conspiracy Mentality Scale scores and the total scores given by this group to the items in the questionnaire about the vaccine conspiracy were significantly higher at the same time. Vaccine hesitancy/resistance was found to be 31–35%, respectively, in a previous study of approximately 3000 people in the UK and Ireland [24]. This study reported that people who experienced vaccine resistance/hesitancy related to a COVID-19 vaccine were less likely to obtain information about the pandemic from reliable sources (such as scientists, healthcare professionals, managers), and their distrust towards these sources of information (conspiracy perspectives) was higher. The relationship between “anti-vaccine” attitudes and distrust towards authority was emphasized, and it was emphasized as an expression of the “anti-authority” attitudes of these people [24]. It may be important for people from different opinions and groups to support vaccine studies as a solution to their attitudes. The importance of religious leaders’ support for vaccine studies has been emphasized in previous studies [37].

Anti-vaccine websites were examined, and speculations were found on human rights violations and possible side effects of vaccines on 76–88% of them in previous studies [38, 39]. The belief that the coronavirus is produced in a laboratory and spread to the world in a planned manner for certain reasons may emerge as an important theory, especially for minds prone to conspiracy theories [18]. It is important to plan the studies on vaccine hesitancy by taking into account these conspiracy theories [28].

A form containing five conspiracy theories that are most on the agenda related to vaccines in Turkey was also created by the study team in parallel with the conspiracy mentality scale in our study. We also found a significant correlation with the conspiracy mentality scale in the scores of this form. Similarly, there was a significant difference in the scores of this form in terms of vaccine attitudes. In other words, people’s general beliefs in conspiracy theories may also be reflected in their ideas about the vaccine. It would be useful to look for ways to spread accurate information about the vaccine in a healthier way in this case.

Conclusion

Vaccine hesitancy is an important public health problem, and it puts public health at risk, especially during the epidemic period we live in. Therefore, it is important to understand the psychological factors involved in vaccine hesitancy. It would be useful to look for ways to spread accurate information about the vaccine in a healthier way in this case.