Literature DB >> 33990387

Nasal expression of SARS-CoV-2 entry receptors in newborns.

Santtu Heinonen1, Otto Helve2, Sture Andersson2, Cecilia Janér2, Liina Süvari2,3, Anu Kaskinen2.   

Abstract

BACKGROUND: SARS-CoV-2 infection is typically mild in children. Lower expression of SARS-CoV-2 entry receptors in the nasal epithelia have been described in children compared with adults. However, data from newborns are lacking. We compared nasal expression of four SARS-CoV-2 entry receptors between term and preterm newborns and adults.
METHODS: Nasal scrape samples were obtained from 28 newborns (17 term and 11 preterm) and 10 adults. Reverse-transcription quantitative PCR was used to measure mRNA expression of ACE2, transmembrane serine protease 2 (TMPRSS2), neuropilin 1 (NRP1) and neuropilin 2 (NRP2) and insulin-like growth factor 1 receptor (IGF1R).
RESULTS: Expression levels of ACE2, TMPRSS2, NRP1 and NRP2 were lower in term and preterm newborns and IGF1R lower in term newborns compared with adults (p<0.05).
CONCLUSIONS: Both term and preterm newborns, compared with adults, have lower expression of SARS-CoV-2 entry receptors in nasal epithelium. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  COVID-19; neonatology

Mesh：

Substances：

Year:  2021        PMID： 33990387     DOI： 10.1136/archdischild-2020-321334

Source DB:  PubMed          Journal:  Arch Dis Child Fetal Neonatal Ed        ISSN： 1359-2998            Impact factor:   5.747


  7 in total

1.  Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels.

Authors:  Mauro G Silva; Nora L Falcoff; Gerardo R Corradi; Norma Di Camillo; Rolando F Seguel; Gabriela C Tabaj; Gabriela R Guman; Elena de Matteo; Myriam Nuñez; Mariela M Gironacci
Journal:  Pediatr Res       Date:  2022-06-23       Impact factor: 3.953

Review 2.  Age-related differences in SARS-CoV-2 binding factors: An explanation for reduced susceptibility to severe COVID-19 among children?

Authors:  Thomas Abrehart; Randy Suryadinata; Conor McCafferty; Jonathan Jacobson; Vera Ignjatovic; Phil Robinson; Nigel W Crawford; Paul Monagle; Kanta Subbarao; Catherine Satzke; Danielle Wurzel
Journal:  Paediatr Respir Rev       Date:  2022-02-08       Impact factor: 2.726

Review 3.  Multisystem Inflammatory Syndrome in Neonates Born to Mothers with SARS-CoV-2 Infection (MIS-N) and in Neonates and Infants Younger Than 6 Months with Acquired COVID-19 (MIS-C): A Systematic Review.

Authors:  Domenico Umberto De Rose; Flaminia Pugnaloni; Monica Calì; Sara Ronci; Stefano Caoci; Chiara Maddaloni; Ludovica Martini; Alessandra Santisi; Andrea Dotta; Cinzia Auriti
Journal:  Viruses       Date:  2022-04-02       Impact factor: 5.818

Review 4.  Routine SARS-CoV-2 vaccination for all children.

Authors:  Kristina De Paris; Sallie R Permar
Journal:  Immunol Rev       Date:  2022-07-07       Impact factor: 10.983

Review 5.  Role of Neuropilin 1 in COVID-19 Patients with Acute Ischemic Stroke.

Authors:  Asma W Al-Thomali; Hayder M Al-Kuraishy; Ali I Al-Gareeb; Ali K Al-Buhadiliy; Michel De Waard; Jean-Marc Sabatier; Atif Ali Khan Khalil; Hebatallah M Saad; Gaber El-Saber Batiha
Journal:  Biomedicines       Date:  2022-08-20

Review 6.  Innate Immunity in Children and the Role of ACE2 Expression in SARS-CoV-2 Infection.

Authors:  Mario Dioguardi; Angela Pia Cazzolla; Claudia Arena; Diego Sovereto; Giorgia Apollonia Caloro; Antonio Dioguardi; Vito Crincoli; Luigi Laino; Giuseppe Troiano; Lorenzo Lo Muzio
Journal:  Pediatr Rep       Date:  2021-07-02

7.  Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society.

Authors:  Ilke Mungan Akin; Mehmet Kenan Kanburoglu; Cuneyt Tayman; Mehmet Yekta Oncel; Timucin Imdadoglu; Mustafa Dilek; Akan Yaman; Fatma Narter; Ilkay Er; Hasan Kahveci; Omer Erdeve; Esin Koc
Journal:  Eur J Pediatr       Date:  2022-01-21       Impact factor: 3.860
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.