Zhe Xu1, Yan Hu2, Bingke Bai2, Mengmeng Qu2, Juan Cheng1, Shengdong Luo2, Zengtao Yao2, Hongyan Gao2, Yenv Ma2, Rong Gao2, Jun Hou2, Shaojie Xin3, Panyong Mao4. 1. Treatment and Research Center for Infectious Diseases, Fifth Medical Center of Chinese, PLA General Hospital, 100 Middle Street of 4th West Ring Road, Beijing, 100039, China. 2. Research Center of Clinical and Translational Medicine, Fifth Medical Center of Chinese, PLA General Hospital, 100 Middle Street of 4th West Ring Road, Beijing, 100039, China. 3. Liver Failure Treatment and Research Center, Fifth Medical Center of Chinese, PLA General Hospital, 100 Middle Street of 4th West Ring Road, Beijing, 100039, China. 4. Research Center of Clinical and Translational Medicine, Fifth Medical Center of Chinese, PLA General Hospital, 100 Middle Street of 4th West Ring Road, Beijing, 100039, China. maopy302@163.com.
Abstract
BACKGROUND: Hematological comparison of coronavirus disease (COVID-19) and other viral pneumonias can provide insights into COVID-19 treatment. METHODS: In this retrospective case-control single-center study, we compared the data of 126 patients with viral pneumonia during different outbreaks [severe acute respiratory syndrome (SARS) in 2003, influenza A (H1N1) in 2009, human adenovirus type 7 in 2018, and COVID-19 in 2020]. RESULTS: One of the COVID-19 characteristics was a continuous decline in the hemoglobin level. The neutrophil count was related to the aggravation of COVID-19 and SARS. Thrombocytopenia occurred in patients with SARS and severe COVID-19 even at the recovery stage. Lymphocytes were related to the entire course of adenovirus infection, recovery of COVID-19, and disease development of SARS. CONCLUSIONS: Dynamic changes in hematological counts could provide a reference for the pathogenesis and prognosis of pneumonia caused by respiratory viruses in clinics.
BACKGROUND: Hematological comparison of coronavirus disease (COVID-19) and other viral pneumonias can provide insights into COVID-19 treatment. METHODS: In this retrospective case-control single-center study, we compared the data of 126 patients with viral pneumonia during different outbreaks [severe acute respiratory syndrome (SARS) in 2003, influenza A (H1N1) in 2009, human adenovirus type 7 in 2018, and COVID-19 in 2020]. RESULTS: One of the COVID-19 characteristics was a continuous decline in the hemoglobin level. The neutrophil count was related to the aggravation of COVID-19 and SARS. Thrombocytopenia occurred in patients with SARS and severe COVID-19 even at the recovery stage. Lymphocytes were related to the entire course of adenovirus infection, recovery of COVID-19, and disease development of SARS. CONCLUSIONS: Dynamic changes in hematological counts could provide a reference for the pathogenesis and prognosis of pneumonia caused by respiratory viruses in clinics.
Authors: Stephanie A Kujawski; Xiaoyan Lu; Eileen Schneider; David Blythe; Sameh Boktor; Janice Farrehi; Thomas Haupt; David McBride; Emily Stephens; Senthilkumar K Sakthivel; Brian Bachaus; Kirsten Waller; Laura Bauman; Agustina Marconi; Rebecca Lewis; Lisa Dettinger; Robert Ernst; William Kinsey; Stephen Lindstrom; Susan I Gerber; John T Watson; Holly M Biggs Journal: Clin Infect Dis Date: 2021-06-01 Impact factor: 9.079
Authors: Kristen K Coleman; Chui Ching Wong; Jayanthi Jayakumar; Tham T Nguyen; Abigail W L Wong; Su Yadana; Koh C Thoon; Kwai Peng Chan; Jenny G Low; Shirin Kalimuddin; Shoaleh Dehghan; June Kang; Amirhossein Shamsaddini; Donald Seto; Yvonne C F Su; Gregory C Gray Journal: J Infect Dis Date: 2020-02-03 Impact factor: 5.226