Sahar Sheikholeslami1, Shaghayegh Khodaverdian1, Masoumeh Dorri-Giv2, Seyyed Mohammad Hosseini3, Shokoufeh Souri4, Razzagh Abedi-Firouzjah5, Hamed Zamani6, Leila Dastranj7, Bagher Farhood8. 1. Department of Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran. 2. Nuclear Medicine Research Center, Department of Nuclear Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 4. Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran. 5. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. 6. Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 7. Department of Physics, Hakim Sabzevari Universuty, Sabzevar, Iran. Electronic address: liladastranj@yahoo.com. 8. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan. Iran. Electronic address: bffarhood@gmail.com.
Abstract
PURPOSE: Radiation therapy is one of the main cancer treatment modalities applied in 50-70% of cancer patients. Despite the many advantages of this treatment, such as non-invasiveness, organ-preservation, and spatiotemporal flexibility in tumor targeting, it can lead to complications in irradiated healthy cells/tissues. In this regard, the use of radio-protective agents can alleviate radiation-induced complications. This study aimed to review the potential role of alpha-lipoic acid in the prevention/reduction of radiation-induced toxicities on healthy cells/tissues. METHODS: A systematic search was performed following PRISMA guidelines to identify relevant literature on the "role of alpha-lipoic acid in the treatment of radiotherapy-induced toxicity" in the electronic databases of Web of Science, Embase, PubMed, and Scopus up to January 2021. Based on the inclusion and exclusion criteria of the present study, 278 articles were screened. Finally, 29 articles were included in this systematic review. RESULTS: The obtained results showed that in experimental in vivo models, the radiation-treated groups had decreased survival rate and body weight compared to the control groups. It was also found that radiation can induce mild to severe toxicities on gastrointestinal, circulatory, reproductive, central nervous, respiratory, endocrine, exocrine systems, etc. However, the use of alpha-lipoic acid could alleviate the radiation-induced toxicities in most cases. This radio-protective agent exerts its effects through mechanisms of anti-oxidant, anti-apoptosis, anti-inflammatory, and so on. CONCLUSION: According to the obtained results, it can be mentioned that co-treatment of alpha-lipoic acid with radiotherapy ameliorates the radiation-induced toxicities in healthy cells/tissues.
PURPOSE: Radiation therapy is one of the main cancer treatment modalities applied in 50-70% of cancer patients. Despite the many advantages of this treatment, such as non-invasiveness, organ-preservation, and spatiotemporal flexibility in tumor targeting, it can lead to complications in irradiated healthy cells/tissues. In this regard, the use of radio-protective agents can alleviate radiation-induced complications. This study aimed to review the potential role of alpha-lipoic acid in the prevention/reduction of radiation-induced toxicities on healthy cells/tissues. METHODS: A systematic search was performed following PRISMA guidelines to identify relevant literature on the "role of alpha-lipoic acid in the treatment of radiotherapy-induced toxicity" in the electronic databases of Web of Science, Embase, PubMed, and Scopus up to January 2021. Based on the inclusion and exclusion criteria of the present study, 278 articles were screened. Finally, 29 articles were included in this systematic review. RESULTS: The obtained results showed that in experimental in vivo models, the radiation-treated groups had decreased survival rate and body weight compared to the control groups. It was also found that radiation can induce mild to severe toxicities on gastrointestinal, circulatory, reproductive, central nervous, respiratory, endocrine, exocrine systems, etc. However, the use of alpha-lipoic acid could alleviate the radiation-induced toxicities in most cases. This radio-protective agent exerts its effects through mechanisms of anti-oxidant, anti-apoptosis, anti-inflammatory, and so on. CONCLUSION: According to the obtained results, it can be mentioned that co-treatment of alpha-lipoic acid with radiotherapy ameliorates the radiation-induced toxicities in healthy cells/tissues.
Authors: Agnieszka Dawczak-Dębicka; Joanna Kufel-Grabowska; Mikołaj Bartoszkiewicz; Adrian Perdyan; Jacek Jassem Journal: Int J Environ Res Public Health Date: 2022-04-21 Impact factor: 4.614
Authors: Elena G Novoselova; Mars G Sharapov; Sergey M Lunin; Svetlana B Parfenyuk; Maxim O Khrenov; Elvira K Mubarakshina; Anna A Kuzekova; Tatyana V Novoselova; Ruslan G Goncharov; Olga V Glushkova Journal: Antioxidants (Basel) Date: 2021-12-05