Literature DB >> 33988992

Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.

George A Naclerio1, Herman O Sintim1,2.   

Abstract

Halogenated phenazines (HPs) are potent antimicrobial agents. A newly developed halogenated phenazine, HP-29, displays remarkable minimum inhibitory concentration (MIC) of 0.08 μM against methicillin-resistant Staphylococcus aureus, MRSA. HP-29 eradicates preformed biofilm via iron starvation, is nontoxic to mammalian cell lines and is efficacious in wound infection models.

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Year:  2021        PMID： 33988992      PMCID： PMC9110258          DOI： 10.1021/acs.jmedchem.1c00749

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   8.039


  6 in total

Review 1.  Mechanisms of biofilm resistance to antimicrobial agents.

Authors:  T F Mah; G A O'Toole
Journal:  Trends Microbiol       Date:  2001-01       Impact factor: 17.079

Review 2.  Antibiotic treatment of biofilm infections.

Authors:  Oana Ciofu; Estrella Rojo-Molinero; María D Macià; Antonio Oliver
Journal:  APMIS       Date:  2017-04       Impact factor: 3.205

3.  Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis.

Authors:  Aaron T Garrison; Yasmeen Abouelhassan; Dimitris Kallifidas; Fang Bai; Maria Ukhanova; Volker Mai; Shouguang Jin; Hendrik Luesch; Robert W Huigens
Journal:  Angew Chem Int Ed Engl       Date:  2015-10-20       Impact factor: 15.336

4.  A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.

Authors:  Hongfen Yang; Shivani Kundra; Michaelle Chojnacki; Ke Liu; Marisa A Fuse; Yasmeen Abouelhassan; Dimitris Kallifidas; Peilan Zhang; Guangtao Huang; Shouguang Jin; Yousong Ding; Hendrik Luesch; Kyle H Rohde; Paul M Dunman; José A Lemos; Robert W Huigens
Journal:  J Med Chem       Date:  2021-04-21       Impact factor: 8.039

5.  Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?

Authors:  Marlieke E A de Kraker; Andrew J Stewardson; Stephan Harbarth
Journal:  PLoS Med       Date:  2016-11-29       Impact factor: 11.069

6.  Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas.

Authors:  Marissa A Valentine-King; Katherine Cisneros; Margaret O James; Robert W Huigens; Mary B Brown
Journal:  BMC Vet Res       Date:  2020-04-06       Impact factor: 2.741
  6 in total
  1 in total

1.  Comparative Studies to Uncover Mechanisms of Action of N-(1,3,4-Oxadiazol-2-yl)benzamide Containing Antibacterial Agents.

Authors:  George A Naclerio; Kenneth I Onyedibe; Caroline W Karanja; Uma K Aryal; Herman O Sintim
Journal:  ACS Infect Dis       Date:  2022-03-17       Impact factor: 5.578
  1 in total

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