Antoine Apert1, Marjorie Canu1, Loic Djaileb2,3, Gilles Barone-Rochette4,5,6, Adrien Jankowski7, Laurent Riou2, Alexis Broisat2, Clemence Charlon1, Caroline Augier1, Aude Boignard1, Julien Leenhardt2,3, Muriel Salvat1, Charlotte Casset1, Marion Maurin1, Carole Saunier1, Gerald Vanzetto1,2,8, Daniel Fagret2,3, Catherine Ghezzi2. 1. Department of Cardiology, University Hospital, Grenoble Alpes, France. 2. Univ. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, Grenoble, 38000, France. 3. Department of Nuclear Medicine, University Hospital, Grenoble Alpes, France. 4. Department of Cardiology, University Hospital, Grenoble Alpes, France. GBarone@chu-grenoble.fr. 5. Univ. Grenoble Alpes, INSERM, CHU Grenoble Alpes, LRB, Grenoble, 38000, France. GBarone@chu-grenoble.fr. 6. French Alliance Clinical Trial, French Clinical Research Infrastructure Network, Paris, France. GBarone@chu-grenoble.fr. 7. Department of Radiology, University Hospital, Grenoble Alpes, France. 8. French Alliance Clinical Trial, French Clinical Research Infrastructure Network, Paris, France.
Abstract
AIMS: The objective of this study was to determine the accuracy of right ventricular function (RVF) assessed by Cadmium Zinc Telluride ECG-gated SPECT equilibrium radionuclide angiocardiography (CZT-ERNA). METHODS AND RESULTS: Twenty-one consecutive patients with cardiomyopathy (aged 54 ± 19 years; 62% male) were included. RV ejection fraction (EF) and volumes were analyzed by CZT-ERNA and compared with values obtained by cardiac magnetic resonance imaging (CMR). Mean values were not different between CZT-ERNA and MRI for RVEF (48.1 ± 10.4% vs 50.8 ± 10.0%; P = .23). Significant correlations (P < .0001) were observed between CZT-ERNA and MRI for RVEF, RV end-diastolic volume, and end-systolic volume (r = 0.81, r = 0.93, and r = 0.96, respectively). Bland-Altman analysis showed a mean difference (bias) between CZT-ERNA and MRI for RVEF of -2.69% (95% CI - 5.35 to - 0.42) with good agreement between the 2 techniques (limits of agreement, -14.3 to 8.99). Intraobserver and interobserver reproducibility of RVF measured by CZT-ERNA was high. CONCLUSION: CZT-ERNA provides accurate, reproducible assessment of RVF and appears as a good alternative to cardiac magnetic resonance for the evaluation of the magnitude of RVF in patients with cardiomyopathy.
AIMS: The objective of this study was to determine the accuracy of right ventricular function (RVF) assessed by Cadmium Zinc Telluride ECG-gated SPECT equilibrium radionuclide angiocardiography (CZT-ERNA). METHODS AND RESULTS: Twenty-one consecutive patients with cardiomyopathy (aged 54 ± 19 years; 62% male) were included. RV ejection fraction (EF) and volumes were analyzed by CZT-ERNA and compared with values obtained by cardiac magnetic resonance imaging (CMR). Mean values were not different between CZT-ERNA and MRI for RVEF (48.1 ± 10.4% vs 50.8 ± 10.0%; P = .23). Significant correlations (P < .0001) were observed between CZT-ERNA and MRI for RVEF, RV end-diastolic volume, and end-systolic volume (r = 0.81, r = 0.93, and r = 0.96, respectively). Bland-Altman analysis showed a mean difference (bias) between CZT-ERNA and MRI for RVEF of -2.69% (95% CI - 5.35 to - 0.42) with good agreement between the 2 techniques (limits of agreement, -14.3 to 8.99). Intraobserver and interobserver reproducibility of RVF measured by CZT-ERNA was high. CONCLUSION: CZT-ERNA provides accurate, reproducible assessment of RVF and appears as a good alternative to cardiac magnetic resonance for the evaluation of the magnitude of RVF in patients with cardiomyopathy.