| Literature DB >> 33988373 |
Michael J Kerner1, Christian A Kuttruff2, Maxim Chevliakov3, Frederic G Buono3, Donghong A Gao4, Mariusz Krawiec4, Carl A Busacca3, Chris H Senanayake3, Peter Wipf1, Jonathan T Reeves3.
Abstract
The addition of carbamoyl anions to azirines affords synthetically useful 2-aziridinyl amide building blocks. The reaction scope was explored with respect to both formamide and azirine, and the addition was found to be highly diastereoselective. A one-pot conversion of a ketoxime to an aziridinyl amide was demonstrated. The method was employed to incorporate an aziridine residue into a dipeptide segment.Entities:
Year: 2021 PMID： 33988373 DOI： 10.1021/acs.orglett.1c01334
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005