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Literature DB >> 3398833

D-3-hydroxybutyrate metabolism in the perfused rat heart.

Abstract

The utilization of D-3-HB and the production of acetoacetate by the perfused rat heart were investigated over a wide range of DL-3-HB concentrations. The rate of D-3-HB utilization is concentration dependent, and shows saturation kinetics. The oxidized amount of D-3-HB when D-3-HB as a sole substrate, accounts at a maximum for 50% of the total oxygen consumption, which suggest the contribution of the endogenous substrate as fuel source along with D-3-HB. The proportion of the D-3-HB consumed that is oxidized rather than released as acetoacetate increases from 70% to 93% as the concentration of D-3-HB falls from 6.99 mM to 0.30 mM.

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Year: 1988 PMID： 3398833 DOI： 10.1007/bf02424552

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

14 in total

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Authors: L H OPIE; J R EVANS; J C SHIPP
Journal: Am J Physiol Date: 1963-12

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Authors: J R WILLIAMSON; H A KREBS
Journal: Biochem J Date: 1961-09 Impact factor: 3.857

3. The oxygen uptake of the perfused rat heart.

Authors: R B FISHER; J R WILLIAMSON
Journal: J Physiol Date: 1961-09 Impact factor: 5.182

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Authors: S L Gartner; G V Vahouny
Journal: Proc Soc Exp Biol Med Date: 1973-06

5. Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles.

Authors: P J Randle; E A Newsholme; P B Garland
Journal: Biochem J Date: 1964-12 Impact factor: 3.857

6. The effects of endogenous and added insulin on the time-course of glucose uptake by the isolated perfused rat heart.

Authors: R B Fisher; J A O'Brien
Journal: Q J Exp Physiol Cogn Med Sci Date: 1972-04

7. Energy state and ultrastructure of the substrate-depleted heart.

Authors: N S Dhalla; J C Yates; R E Olson
Journal: Recent Adv Stud Cardiac Struct Metab Date: 1972

8. The mechanism of ammonia production and the effect of mechanical work load on proteolysis and amino acid catabolism in isolated perfused rat heart.

Authors: T Takala; J K Hiltunen; I E Hassinen
Journal: Biochem J Date: 1980-10-15 Impact factor: 3.857

9. Hormonal control of lipid concentration in rat heart and gastrocnemius.

Authors: R M Denton; P J Randle
Journal: Nature Date: 1965-10-30 Impact factor: 49.962

10. Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusion.

Authors: R M Denton; P J Randle
Journal: Biochem J Date: 1967-08 Impact factor: 3.857

6 in total

6. Quantitative Proteomics Analysis Expands the Roles of Lysine β-Hydroxybutyrylation Pathway in Response to Environmental β-Hydroxybutyrate.

Authors: Wanting Hou; Guobin Liu; Xuelian Ren; Xianming Liu; Lei He; He Huang
Journal: Oxid Med Cell Longev Date: 2022-02-24 Impact factor: 6.543