Matthias Maus1, Ludwig M Heindl2,3, Hasan Chichan2,1. 1. Sehkraft Eye Center, Cologne, 50667, Germany. 2. Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, 50923, Germany. 3. Center for Integrated Oncology (CIO) Aachen-Bonn-Cologne-Duesseldorf, Cologne, 50937, Germany.
Abstract
BACKGROUND: Age-related macular degeneration (AMD), a degenerative disorder, is a major cause of irreversible severe visual deterioration in the older Western population. Thus, treatments that resolve drusen may prove helpful in limiting the progression of AMD. The study aimed to evaluate the clinical outcome of sub-threshold nanosecond laser therapy (SNL) using a double-frequency nanosecond-pulsed laser with discontinuous energy beam distribution in the early stages of age-related macular degeneration (AMD). METHODS: In a single-center cohort study, 64 eyes with early or intermediate AMD were treated using SNL and then compared to 77 untreated, control eyes. The primary outcome measures included the area and amount of drusen, and the secondary outcome measures included change in visual acuity and rate of drusen progression within 6 months of follow-up. RESULTS: A total of 64 patients' eyes following SNL treatment showed a significant reduction in the area and amount of drusen after 6 months in comparison to the corresponding values in the control group (p<0.001, respectively). There was no significant difference in visual acuity change after 6 months in both groups (p0.59, respectively). Within the 6-month follow-up, the rate of progression in drusen size and number was significantly lower in the SNL group (26%) than in the control group (69%; p<0.001). DISCUSSION: SNL therapy is a novel, promising approach for improving the macular morphology in patients with early and intermediate AMD. Further studies are necessary to reveal the potential to reduce the risk of transformation into advanced or wet AMD and to retain vision.
BACKGROUND: Age-related macular degeneration (AMD), a degenerative disorder, is a major cause of irreversible severe visual deterioration in the older Western population. Thus, treatments that resolve drusen may prove helpful in limiting the progression of AMD. The study aimed to evaluate the clinical outcome of sub-threshold nanosecond laser therapy (SNL) using a double-frequency nanosecond-pulsed laser with discontinuous energy beam distribution in the early stages of age-related macular degeneration (AMD). METHODS: In a single-center cohort study, 64 eyes with early or intermediate AMD were treated using SNL and then compared to 77 untreated, control eyes. The primary outcome measures included the area and amount of drusen, and the secondary outcome measures included change in visual acuity and rate of drusen progression within 6 months of follow-up. RESULTS: A total of 64 patients' eyes following SNL treatment showed a significant reduction in the area and amount of drusen after 6 months in comparison to the corresponding values in the control group (p<0.001, respectively). There was no significant difference in visual acuity change after 6 months in both groups (p0.59, respectively). Within the 6-month follow-up, the rate of progression in drusen size and number was significantly lower in the SNL group (26%) than in the control group (69%; p<0.001). DISCUSSION: SNL therapy is a novel, promising approach for improving the macular morphology in patients with early and intermediate AMD. Further studies are necessary to reveal the potential to reduce the risk of transformation into advanced or wet AMD and to retain vision.
Authors: A I Jobling; R H Guymer; K A Vessey; U Greferath; S A Mills; K H Brassington; C D Luu; K Z Aung; L Trogrlic; M Plunkett; E L Fletcher Journal: FASEB J Date: 2014-11-12 Impact factor: 5.191
Authors: John P M Wood; O'Sam Shibeeb; Malcolm Plunkett; Robert J Casson; Glyn Chidlow Journal: Invest Ophthalmol Vis Sci Date: 2013-03-28 Impact factor: 4.799
Authors: Robyn H Guymer; Zhichao Wu; Lauren A B Hodgson; Emily Caruso; Kate H Brassington; Nicole Tindill; Khin Zaw Aung; Myra B McGuinness; Erica L Fletcher; Fred K Chen; Usha Chakravarthy; Jennifer J Arnold; Wilson J Heriot; Shane R Durkin; Jia Jia Lek; Colin A Harper; Sanjeewa S Wickremasinghe; Sukhpal S Sandhu; Elizabeth K Baglin; Pyrawy Sharangan; Sabine Braat; Chi D Luu Journal: Ophthalmology Date: 2018-09-20 Impact factor: 12.079