| Literature DB >> 33985614 |
Sedighe Karimzadeh1, Raj Bhopal2, Huy Nguyen Tien3.
Abstract
Entities:
Year: 2021 PMID: 33985614 PMCID: PMC8129670 DOI: 10.1017/S0950268821001084
Source DB: PubMed Journal: Epidemiol Infect ISSN: 0950-2688 Impact factor: 2.451
Experimental studies on the infective dose of coronaviruses in various mammals
| Virus | Host | Dose (PFU) | Route of inoculation | Numbers and/or %, signs of infection | References |
|---|---|---|---|---|---|
| SARS-CoV-2 | aFerret | 221 359 | IN | 6/6 | Kim [16] |
| 500 | IN | 16.7,1/6 | Ryan [17] | ||
| 50 000 | IN | 6/6 | |||
| 5 000 000 | IN | 6/6 | |||
| 420 000 | IN | 4/4 | Richard [18] | ||
| SARS-CoV-2 HCoV-OC43 | bhACE2 mice | 70 000 | IN | 36.8,7/19 | Bao [19] |
| 400 000 | IN | 3/3 | Sun [20] | ||
| 4 000 000 | IG | 1/3 | |||
| 630 | Aerosol | 2/2 | Bao [21] | ||
| 21 000 | IN | 50% Lethal | Jiang [22] | ||
| 100 000 | IN | 40% Lethal | Dinnon [23] | ||
| BALB/c mice | 16 000 | IN | 3/3 | Gu [24] | |
| BALB/c and C57B6 mice | 70 000 | IP/IC | 100% Lethal | Jacomy [25] | |
| BALB/c mice | 70 | IC | 100% Lethal | Shen [26] | |
| SARS-CoV-1 | tgMice | 280 | IN | NR | Watanabe [8] |
| MERS-CoV | tgMice | 0.7 | IN | NR | Tao [27] |
| 7 | IN | 50% Lethal | |||
| SARS-CoV-2 | cCynomolgus macaques | 48 600 | Aerosol | 4/4 | Johnston [28] |
| 700 000 | IN/IT | 4/4 | Rockx [29] | ||
| SARS-CoV-2 | dRhesus macaques | 700 000 | IO | 2/2 | Deng [30] |
| IT | 1/1 | ||||
| IG | 0/2 | ||||
| 1 820 000 | IN/IT/IO/Oral | 8/8 | Munster [31] | ||
| 11 000 | IN/IT | 3/3 | Chandrashekar [32] | ||
| 110 000 | IN/IT | 3/3 | |||
| 1 100 000 | IN/IT | 3/3 | |||
| 28 700 | Aerosol | 4/4 | Johanston [28] | ||
| SARS-CoV-2 | eAfrican green monkeys | 38 000 | Aerosol | 3/3 | Johanston [28] |
| 500 000 | IN/IT | 6/6 | Woolsey [33] | ||
| 3 000 000 | IN | 6/6 | Cross [34] | ||
| 2000 | Aerosol | 2/2 | Blair [35] | ||
| 3 610 000 | IO/IT/IN/Oral | 2/2 | |||
| SARS-CoV-2 | fSyrian hamster | 398 107 | IN/IO | 4/4 | Imai [36] |
| 1000 | IN/IO | 4/4 | |||
| 56 000 | IN | 3/3 | Sia [37] | ||
| 100 000 | IN | 75,24/36 | Osterrieder [38] | ||
| Immunocompromised syrian hamster | 100 | IN | 10/10 | Brocato [39] | |
| 1000 | IN | ||||
| 10 000 | IN | 40% Lethal | |||
| gBats | 70 000 | IN | 78,7/9 | Schlottau [40] |
TCID50, %50 tissue infective culture dose; PFU, plaque-forming units; tgMice, transgenic mice; hACE2, human angiotensin converting enzyme 2, BALB/c; begg albino laboratory-bred mouse, IN; intranasal, IG; intragastric, IO; intraocular, IT; intrathecal, IC; intracerebral, IP; intraperitoneal, NR; not reported.