| Literature DB >> 339828 |
Abstract
The widely used E. coli K12 strain AB1157 is impaired in guanine (xnathine) metabolism. Mutants blocked in purine biosynthesis before the stage of inosine monophosphate synthesis do not grow on external guanine or xanthine. The genetic nature of the Gua/Xan lesion is a deletion in the chromosome that covers the proA gene. The lesion causes reduced uptake of guanine.Entities:
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Year: 1977 PMID: 339828 DOI: 10.1007/bf00395674
Source DB: PubMed Journal: Antonie Van Leeuwenhoek ISSN: 0003-6072 Impact factor: 2.271