| Literature DB >> 33980468 |
Abstract
How does the immune system tailor effector function to particular threats? Krueger et al. reveal that infection with Salmonella enterica (SE), but not with influenza A virus (IAV), drives interleukin (IL)-12-dependent outgrowth of interferon (IFN)-γhi type 1 T helper (Th1) cells, leading to superior protection against this phagosomal pathogen. Among these cells are ZEB2-dependent cytotoxic Th1 cells marked by CX3CR1 expression.Entities:
Keywords: CX3CR1; IL-12; T helper cells; ZEB2; cytotoxic CD4 T cells; phagosomal pathogens
Year: 2021 PMID： 33980468 DOI： 10.1016/j.it.2021.04.008
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687