| Literature DB >> 33977992 |
Benjamin Bailly1, Anil K Gorle1, Larissa Dirr1, Alpeshkumar K Malde1, Nicholas P Farrell2, Susan J Berners-Price1, Mark von Itzstein1.
Abstract
We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell-surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development.Entities:
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Year: 2021 PMID： 33977992 DOI： 10.1039/d1cc01593a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222