Nan Yao1, Shoumeng Yan1, Yinpei Guo1, Han Wang1, Xiaotong Li1, Ling Wang1, Wenyu Hu1, Bo Li1, Weiwei Cui2. 1. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, P. R. China. li_bo@jlu.edu.cn. 2. Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, 130021, P. R. China. cuiweiwei@jlu.edu.cn.
Abstract
BACKGROUND: Excess body weight, including overweight and obesity, is one of the major factors influencing human health, and plays an important role in the global burden of disease. Carotenoids serve as precursors of vitamin A-related retinoids, and are considered to have potential effects on many diseases. However, the influence of carotenoids on people with excess body weight is unclear. METHODS: This meta-analysis was conducted to assess the effects of carotenoids on overweight or obese subjects utilizing the available evidence. We searched PubMed, Medline, Cochrane Library, Web of Science and EMBASE databases up to September 2020. Random effects models were used to calculate the standard mean differences (SMDs) and odds ratios (ORs) with their 95% confidence intervals (95% CIs). RESULTS: A total of seven randomized controlled trials and eight observational studies met the inclusion criteria and contained 28 944 subjects and data on multiple carotenoid subgroups, including lycopene, astaxanthin, cryptoxanthin, α-carotene, and β-carotene. In all included Randomized Controlled Trial (RCT), the intervention duration was 20 days at the shortest and 16 weeks at the longest, and the range of intervention doses was 1.2-60 mg d-1. Our study found that the insufficiency of serum carotenoids was a risk factor for overweight and obesity (OR = 1.73, 95% CI [1.57, 1.91], p < 0.001). Moreover, carotenoid supplementation was significantly associated with body weight reductions (SMD = -2.34 kg, 95% CI [-3.80, -0.87] kg, p < 0.001), body mass index decrease (BMI, SMD = -0.95 kg cm-2, 95% CI [-1.88, -0.01] kg cm-2, p < 0.001) and waist circumference losses (WC, SMD = -1.84 cm, 95% CI [-3.14, -0.54]cm, p < 0.001). CONCLUSION: In summary, the carotenoids show promising effects in overweight or obese subjects. Additional data from large clinical trials are needed.
BACKGROUND: Excess body weight, including overweight and obesity, is one of the major factors influencing human health, and plays an important role in the global burden of disease. Carotenoids serve as precursors of vitamin A-related retinoids, and are considered to have potential effects on many diseases. However, the influence of carotenoids on people with excess body weight is unclear. METHODS: This meta-analysis was conducted to assess the effects of carotenoids on overweight or obese subjects utilizing the available evidence. We searched PubMed, Medline, Cochrane Library, Web of Science and EMBASE databases up to September 2020. Random effects models were used to calculate the standard mean differences (SMDs) and odds ratios (ORs) with their 95% confidence intervals (95% CIs). RESULTS: A total of seven randomized controlled trials and eight observational studies met the inclusion criteria and contained 28 944 subjects and data on multiple carotenoid subgroups, including lycopene, astaxanthin, cryptoxanthin, α-carotene, and β-carotene. In all included Randomized Controlled Trial (RCT), the intervention duration was 20 days at the shortest and 16 weeks at the longest, and the range of intervention doses was 1.2-60 mg d-1. Our study found that the insufficiency of serum carotenoids was a risk factor for overweight and obesity (OR = 1.73, 95% CI [1.57, 1.91], p < 0.001). Moreover, carotenoid supplementation was significantly associated with body weight reductions (SMD = -2.34 kg, 95% CI [-3.80, -0.87] kg, p < 0.001), body mass index decrease (BMI, SMD = -0.95 kg cm-2, 95% CI [-1.88, -0.01] kg cm-2, p < 0.001) and waist circumference losses (WC, SMD = -1.84 cm, 95% CI [-3.14, -0.54]cm, p < 0.001). CONCLUSION: In summary, the carotenoids show promising effects in overweight or obese subjects. Additional data from large clinical trials are needed.
Authors: Aline B Santamarina; Leonardo M de Souza Mesquita; Breno P Casagrande; Marcela N Sertorio; Daniel Vitor de Souza; Laís V Mennitti; Daniel A Ribeiro; Débora Estadella; Sónia P M Ventura; Veridiana V de Rosso; Luciana P Pisani Journal: Food Chem X Date: 2022-02-04
Authors: Louise W Lu; Yao Gao; Siew-Young Quek; Meika Foster; Charles T Eason; Min Liu; Mingfu Wang; Jie-Hua Chen; Feng Chen Journal: Biomed Pharmacother Date: 2022-08-31 Impact factor: 7.419
Authors: María Marhuenda-Muñoz; Inés Domínguez-López; Klaus Langohr; Anna Tresserra-Rimbau; Miguel Ángel Martínez González; Jordi Salas-Salvadó; Dolores Corella; María Dolores Zomeño; J Alfredo Martínez; Angel M Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramón Estruch; Francisco J Tinahones; José Lapetra; Ll Serra-Majem; Aurora Bueno-Cavanillas; Josep A Tur; Vicente Martín-Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Emilio Ros; Estefanía Toledo; María Fernández de la Puente Cervera; Rocío Barragán; Montse Fitó; Lucas Tojal-Sierra; Enrique Gómez-Gracia; Juan Manuel Zazo; Marga Morey; Antonio García-Ríos; Rosa Casas; Ana M Gómez-Pérez; José Manuel Santos-Lozano; Zenaida Vázquez-Ruiz; Alessandro Atzeni; Eva M Asensio; M Mar Gili-Riu; Vanessa Bullon; Anai Moreno-Rodriguez; Oscar Lecea; Nancy Babio; Francesca Peñas Lopez; Guadalupe Gómez Melis; Rosa M Lamuela-Raventós Journal: Front Nutr Date: 2022-09-29