Sagi Tshori1,2, Shay Livschitz3, Igor Volodarsky3, Sorel Goland3,4, Sara Shimoni3,4, Jacob Fabrikant3, Jacob George5,6. 1. Heart Center, Kaplan Medical Center, Pasternak St., 1, Rehovot, 7661041, Israel. sagit@ekmd.huji.ac.il. 2. Institute of Medical Research Israel-Canada, The Hebrew University, Jerusalem, Israel. sagit@ekmd.huji.ac.il. 3. Heart Center, Kaplan Medical Center, Pasternak St., 1, Rehovot, 7661041, Israel. 4. The Hebrew University, Jerusalem, Israel. 5. Heart Center, Kaplan Medical Center, Pasternak St., 1, Rehovot, 7661041, Israel. jgeorge@bezeqint.net. 6. The Hebrew University, Jerusalem, Israel. jgeorge@bezeqint.net.
Abstract
BACKGROUND: Bone scintigraphy is a main diagnostic tool in suspected ATTR patients. Almost all literature is based on conventional whole body gamma cameras, and there is very sparse data evaluating the use of dedicated cardiac CZT cameras. The aim of this study was to evaluate the utility of bone scintigraphy in suspected transthyretin cardiac amyloidosis (ATTR-CA) patients on a dedicated cardiac CZT camera. METHODS: Seventy-three patients with suspected ATTR-CA underwent planar and SPECT Tc-99 m pyrophosphate scintigraphy using dedicated cardiac CZT camera between May and August 2019. RESULTS: Planar D-SPECT image quality was mostly good. Six patients were identified as ATTR-CA positive. Inter-observer agreement based on both Perugini score and on planar D-SPECT H/CL ratio was excellent. CONCLUSIONS: ATTR-CA scintigraphy using dedicated cardiac CZT camera was feasible, and yielded planar D-SPECT images with excellent inter-observer agreement.
BACKGROUND: Bone scintigraphy is a main diagnostic tool in suspected ATTR patients. Almost all literature is based on conventional whole body gamma cameras, and there is very sparse data evaluating the use of dedicated cardiac CZT cameras. The aim of this study was to evaluate the utility of bone scintigraphy in suspected transthyretin cardiac amyloidosis (ATTR-CA) patients on a dedicated cardiac CZT camera. METHODS: Seventy-three patients with suspected ATTR-CA underwent planar and SPECT Tc-99 m pyrophosphate scintigraphy using dedicated cardiac CZT camera between May and August 2019. RESULTS: Planar D-SPECT image quality was mostly good. Six patients were identified as ATTR-CA positive. Inter-observer agreement based on both Perugini score and on planar D-SPECT H/CL ratio was excellent. CONCLUSIONS: ATTR-CA scintigraphy using dedicated cardiac CZT camera was feasible, and yielded planar D-SPECT images with excellent inter-observer agreement.