Hui Zhang1,2, Hangqi Shen3,4,5,6,7, Wei Gong3,4,5,6,7, Xuehui Sun1,2, Xiaoyan Jiang8, Jiucun Wang1,2, Li Jin1,2, Xun Xu9,10,11,12,13, Dawei Luo14,15,16,17,18, Xiaofeng Wang19,20,21,22. 1. State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China. 2. Human Phenome Institute, Fudan University, Shanghai, China. 3. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4. Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. 5. Shanghai Engineering Center for Visual Science and Photomedicin, Shanghai, China. 6. Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 7. National Clinical Research Center for Eye Diseases, Shanghai, China. 8. Key Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University School of Medicine, Shanghai, China. 9. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. drxuxun@sjtu.edu.cn. 10. Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. drxuxun@sjtu.edu.cn. 11. Shanghai Engineering Center for Visual Science and Photomedicin, Shanghai, China. drxuxun@sjtu.edu.cn. 12. Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. drxuxun@sjtu.edu.cn. 13. National Clinical Research Center for Eye Diseases, Shanghai, China. drxuxun@sjtu.edu.cn. 14. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. dr-davie@yeah.net. 15. Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. dr-davie@yeah.net. 16. Shanghai Engineering Center for Visual Science and Photomedicin, Shanghai, China. dr-davie@yeah.net. 17. Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. dr-davie@yeah.net. 18. National Clinical Research Center for Eye Diseases, Shanghai, China. dr-davie@yeah.net. 19. State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China. xiaofengwang71@163.com. 20. Human Phenome Institute, Fudan University, Shanghai, China. xiaofengwang71@163.com. 21. Shanghai Key Laboratory of Clinical Geriatric Medicine and Huadong Hospital Clinical Research Center for Geriatric Medicine, Shanghai, China. xiaofengwang71@163.com. 22. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. xiaofengwang71@163.com.
Abstract
OBJECTIVES: To determine the association of plasma homocysteine levels with retinal layer thickness in a large community cohort of older adults. METHODS: The Rugao Longevity and Ageing Study is an observational, prospective and community-based cohort study. A total of 989 older adults who underwent spectral-domain optical coherence tomography (SD-OCT) were included and analyzed. Foveal, macular retinal nerve fibre layer (mRNFL) and ganglion cell layer plus inner plexiform layer (GC-IPL) thicknesses were measured by SD-OCT. Plasma homocysteine levels were measured using chemiluminescence immunoassay. Linear regression analyses were performed to evaluate the relationship between plasma homocysteine and retinal layer thickness while controlling for confounding factors. RESULTS: Of the 989 participants, 500 (50.56%) were men. The mean age was 78.26 (4.58) years, and the mean plasma homocysteine level was 16.38 (8.05) μmol/L. In multivariable analyses, each unit increase in plasma homocysteine was associated with an 8.84 × 10-2 (95% CI: -16.54 × 10-2 to -1.15 × 10-2, p = 0.032) μm decrease in the average inner thickness of the GC-IPL after controlling for confounding factors. The association remained significant even in participants without major cardiovascular disease or diabetes (β = -10.33 × 10-2, 95% CI: -18.49 × 10-2 to -2.18 × 10-2, p = 0.013). No significant associations of plasma homocysteine levels with macular thickness or mRNFL were found in primary and sensitivity analyses (p > 0.05). CONCLUSIONS: Increased plasma homocysteine levels are associated with a thinner GC-IPL. Plasma homocysteine may be a risk factor for thinner retinas in older adults.
OBJECTIVES: To determine the association of plasma homocysteine levels with retinal layer thickness in a large community cohort of older adults. METHODS: The Rugao Longevity and Ageing Study is an observational, prospective and community-based cohort study. A total of 989 older adults who underwent spectral-domain optical coherence tomography (SD-OCT) were included and analyzed. Foveal, macular retinal nerve fibre layer (mRNFL) and ganglion cell layer plus inner plexiform layer (GC-IPL) thicknesses were measured by SD-OCT. Plasma homocysteine levels were measured using chemiluminescence immunoassay. Linear regression analyses were performed to evaluate the relationship between plasma homocysteine and retinal layer thickness while controlling for confounding factors. RESULTS: Of the 989 participants, 500 (50.56%) were men. The mean age was 78.26 (4.58) years, and the mean plasma homocysteine level was 16.38 (8.05) μmol/L. In multivariable analyses, each unit increase in plasma homocysteine was associated with an 8.84 × 10-2 (95% CI: -16.54 × 10-2 to -1.15 × 10-2, p = 0.032) μm decrease in the average inner thickness of the GC-IPL after controlling for confounding factors. The association remained significant even in participants without major cardiovascular disease or diabetes (β = -10.33 × 10-2, 95% CI: -18.49 × 10-2 to -2.18 × 10-2, p = 0.013). No significant associations of plasma homocysteine levels with macular thickness or mRNFL were found in primary and sensitivity analyses (p > 0.05). CONCLUSIONS: Increased plasma homocysteine levels are associated with a thinner GC-IPL. Plasma homocysteine may be a risk factor for thinner retinas in older adults.
Authors: S A Lipton; W K Kim; Y B Choi; S Kumar; D M D'Emilia; P V Rayudu; D R Arnelle; J S Stamler Journal: Proc Natl Acad Sci U S A Date: 1997-05-27 Impact factor: 11.205
Authors: Marta Pazos; Agnieszka Anna Dyrda; Marc Biarnés; Alicia Gómez; Carlos Martín; Clara Mora; Gianluca Fatti; Alfonso Antón Journal: Ophthalmology Date: 2017-04-29 Impact factor: 12.079
Authors: Preethi S Ganapathy; Richard E White; Yonju Ha; B Renee Bozard; Paul L McNeil; R William Caldwell; Sanjiv Kumar; Stephen M Black; Sylvia B Smith Journal: Invest Ophthalmol Vis Sci Date: 2011-07-25 Impact factor: 4.799