Literature DB >> 3397543

Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells.

K Okazaki1, S Nishikawa, H Sakano.   

Abstract

We have analyzed Ig gene rearrangement in the immunodeficient mutant mouse, CB-17 scid. Bone marrow stem cells from scid mice were cultured in the in vitro culture system of Whitlock and Witte. Ig gene rearrangement in the scid cells was studied by DNA cloning. Seven DNA clones of Ig H chain JH and DH regions were analyzed by DNA sequencing, and all the clones contained a failure in D-J joining. In the rearranged structure, both DH and JH coding sequences are either partly or completely deleted. Molecular mechanisms causing the aberrant DNA rearrangement are discussed.

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Year:  1988        PMID： 3397543

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  24 in total

Review 1.  SCID mice in the study of human autoimmune diseases.

Authors:  M A Duchosal
Journal:  Springer Semin Immunopathol       Date:  1992

2.  Strand breaks without DNA rearrangement in V (D)J recombination.

Authors:  E A Hendrickson; V F Liu; D T Weaver
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

3.  Wild-type V(D)J recombination in scid pre-B cells.

Authors:  E A Hendrickson; M S Schlissel; D T Weaver
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

4.  HMG1-related DNA-binding protein isolated with V-(D)-J recombination signal probes.

Authors:  M Shirakata; K Hüppi; S Usuda; K Okazaki; K Yoshida; H Sakano
Journal:  Mol Cell Biol       Date:  1991-09       Impact factor: 4.272

5.  Efficient nonhomologous and homologous recombination in scid cells.

Authors:  B Bühler; G Köhler; P J Nielsen
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

6.  The mouse mutation severe combined immune deficiency (scid) is on chromosome 16.

Authors:  G C Bosma; M T Davisson; N R Ruetsch; H O Sweet; L D Shultz; M J Bosma
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

7.  Biased T-cell receptor delta element recombination in scid thymocytes.

Authors:  A M Carroll; J K Slack; W T Chang
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

Review 8.  In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice.

Authors:  T S Barry; B F Haynes
Journal:  J Clin Immunol       Date:  1992-09       Impact factor: 8.317

9.  Differential responses of p56lyn and p53lyn, products of alternatively spliced lyn mRNA, on stimulation of B-cell antigen receptor.

Authors:  Y Yamanashi; M Miyasaka; M Takeuchi; D Ilic; J Mizuguchi; T Yamamoto
Journal:  Cell Regul       Date:  1991-12

10.  Analysis of the defect in DNA end joining in the murine scid mutation.

Authors:  J Harrington; C L Hsieh; J Gerton; G Bosma; M R Lieber
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272
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