Literature DB >> 33972255

A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole.

Iker Falces-Romero1, Jesús Mingorance1, Julio García-Rodríguez1, Emilio Cendejas-Bueno1.   

Abstract

We present a proof-of-concept study on the use of MALDI Biotyper to detect and monitor the levels of voriconazole in human serum. A simple extraction-concentration method and a MALDI Biotyper protocol were developed, and a parent ion of voriconazole (1 H+) could be detected and quantified with good reproducibility. Our results point to a new application of MALDI Biotyper for therapeutic drug monitoring.

Entities:  

Keywords:  MALDI Biotyper; new development; therapeutic drug monitoring; voriconazole

Mesh：

Substances：

Year:  2021        PMID： 33972255      PMCID： PMC8284431          DOI： 10.1128/AAC.02458-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Development and validation of a fast HPLC/photodiode array detection method for the measurement of voriconazole in human serum samples. A reference laboratory experience.

Authors:  Emilio Cendejas-Bueno; Juan L Rodríguez-Tudela; Manuel Cuenca-Estrella; Alicia Gómez-López
Journal:  Enferm Infecc Microbiol Clin       Date:  2012-07-08       Impact factor: 1.731

Review 2.  Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations.

Authors:  Katharine E Stott; William W Hope
Journal:  J Antimicrob Chemother       Date:  2017-03-01       Impact factor: 5.790

3.  Determination of voriconazole serum concentration by bioassay, a valid method for therapeutic drug monitoring for clinical laboratories.

Authors:  Emilio Cendejas-Bueno; Manuel Cuenca-Estrella; Alicia Gomez-Lopez
Journal:  Antimicrob Agents Chemother       Date:  2013-05-06       Impact factor: 5.191

Review 4.  Application of the MALDI Biotyper to clinical microbiology: progress and potential.

Authors:  Markus Kostrzewa
Journal:  Expert Rev Proteomics       Date:  2018-02-13       Impact factor: 3.940

Review 5.  [Clinical indications for therapeutic drug monitoring of antifungal agents. In the way for optimizing the treatment of fungal infection].

Authors:  E Cendejas-Bueno; M Cuenca-Estrella; A Gómez-López
Journal:  Rev Esp Quimioter       Date:  2014-03       Impact factor: 1.553

6.  Plasma Voriconazole Estimation by HPLC.

Authors:  Prerna K Chawla; Alpa J Dherai; Tester F Ashavaid
Journal:  Indian J Clin Biochem       Date:  2015-05-01
  6 in total

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