Literature DB >> 33972239

Efficacy of Omadacycline against Escherichia coli in a Mouse Urinary Tract Infection Model.

Kavindra V Singh1,2, Barbara E Murray1,3,2.   

Abstract

In a mouse urinary tract infection model, omadacycline (OMC) was comparable to gentamicin and better than ciprofloxacin (CIP) against a tetracycline-susceptible (TET-S), CIP-resistant (CIP-R) Escherichia coli strain. Gentamicin showed better efficacy than OMC against a TET-R, CIP-R E. coli strain, and OMC again showed better efficacy than CIP against this strain. OMC may warrant further study as a potential option for urinary tract infection treatment against CIP-R E. coli strains.

Entities:  

Keywords:  Escherichia coli; mouse UTI; omadacycline

Mesh：

Substances：

Year:  2021        PMID： 33972239      PMCID： PMC8218671          DOI： 10.1128/AAC.00269-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Surveillance of Omadacycline Activity Tested against Clinical Isolates from the United States and Europe: Report from the SENTRY Antimicrobial Surveillance Program, 2016 to 2018.

Authors:  Michael A Pfaller; Michael D Huband; Dee Shortridge; Robert K Flamm
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

2.  Activity of omadacycline tested against Enterobacteriaceae causing urinary tract infections from a global surveillance program (2014).

Authors:  M A Pfaller; P R Rhomberg; M D Huband; R K Flamm
Journal:  Diagn Microbiol Infect Dis       Date:  2018-02-24       Impact factor: 2.803

3.  Efficacy of ceftobiprole Medocaril against Enterococcus faecalis in a murine urinary tract infection model.

Authors:  Kavindra V Singh; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2012-03-26       Impact factor: 5.191

Review 4.  Molecular epidemiology of Escherichia coli mediated urinary tract infections.

Authors:  Lixin Zhang; Betsy Foxman
Journal:  Front Biosci       Date:  2003-01-01

5.  Importance of the ebp (endocarditis- and biofilm-associated pilus) locus in the pathogenesis of Enterococcus faecalis ascending urinary tract infection.

Authors:  Kavindra V Singh; Sreedhar R Nallapareddy; Barbara E Murray
Journal:  J Infect Dis       Date:  2007-04-26       Impact factor: 5.226

6.  Ampicillin plus ceftriaxone is as effective as ampicillin plus gentamicin for treating enterococcus faecalis infective endocarditis.

Authors:  Nuria Fernández-Hidalgo; Benito Almirante; Joan Gavaldà; Mercè Gurgui; Carmen Peña; Arístides de Alarcón; Josefa Ruiz; Isidre Vilacosta; Miguel Montejo; Nuria Vallejo; Francisco López-Medrano; Antonio Plata; Javier López; Carmen Hidalgo-Tenorio; Juan Gálvez; Carmen Sáez; José Manuel Lomas; Marco Falcone; Javier de la Torre; Xavier Martínez-Lacasa; Albert Pahissa
Journal:  Clin Infect Dis       Date:  2013-02-07       Impact factor: 9.079

7.  In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis.

Authors:  Judith Steenbergen; S Ken Tanaka; Lynda L Miller; Stephanie A Halasohoris; Jeremy R Hershfield
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

8.  Microbiology and Preclinical Review of Omadacycline.

Authors:  James A Karlowsky; Judith Steenbergen; George G Zhanel
Journal:  Clin Infect Dis       Date:  2019-08-01       Impact factor: 9.079

Review 9.  An introduction to the epidemiology and burden of urinary tract infections.

Authors:  Martha Medina; Edgardo Castillo-Pino
Journal:  Ther Adv Urol       Date:  2019-05-02

10.  Omadacycline: A Modernized Tetracycline.

Authors:  Jason C Gallagher
Journal:  Clin Infect Dis       Date:  2019-08-01       Impact factor: 9.079
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