| Literature DB >> 33972165 |
Paulo Henrique Rosa da Silva1, Bruna Cristina Borges1, Isadora Akemi Uehara1, Luiz Ricardo Soldi1, Rogério Agenor de Araújo1, Marcelo José Barbosa Silva2.
Abstract
The extracellular matrix (ECM) consists of various molecules that support tissue cells, including proteins, fibronectin, laminin, collagen IV, and glycosaminoglycans. In addition to interactions between the ECM and cells, the ECM also interacts with chemokines, and growth factors, and these interactions ensure cell survival, development, differentiation, and migration of both immune system cells and tumor cells. This review provides an overview of the mechanisms of interaction between the ECM and chemokines, focusing on the tumor microenvironment and the modulation of these elements as a target for therapies in several types of cancer.Entities:
Keywords: Adherence; Chemokines; Extracellular matrix; Progress; Recruitment; Tumor
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Year: 2021 PMID： 33972165 DOI： 10.1016/j.cyto.2021.155548
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861