| Literature DB >> 33972153 |
Douglas L Miller1, Chunyan Dou2, Krishnan Raghavendran3, Zhihong Dong2.
Abstract
Induction of pulmonary capillary hemorrhage (PCH) by lung ultrasound (LUS) depends not only on physical exposure parameters but also on physiologic conditions and drug treatment. We studied the influence of xylazine and clonidine on LUS-induced PCH in spontaneously hypertensive and normotensive rats using diagnostic B-mode ultrasound at 7.3 MHz. Using ketamine anesthesia, rats receiving saline, xylazine, or clonidine treatment were tested with different pulse peak rarefactional pressure amplitudes in 5 min exposures. Results with xylazine or clonidine in spontaneously hypertensive rats were not significantly different at the three exposure pulse peak rarefactional pressure amplitudes, and thresholds were lower (2.2 MPa) than with saline (2.6 MPa). Variations in LUS PCH were not correlated with mean systemic blood pressure. Similar to previous findings for dexmedetomidine, the clinical drug clonidine tended to increase susceptibility to LUS PCH.Entities:
Keywords: B-lines; Bioeffects of ultrasound; Diagnostic ultrasound safety; Lung ultrasound; Point-of-care ultrasound; Ultrasound dosimetry
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Year: 2021 PMID： 33972153 PMCID： PMC8243848 DOI： 10.1016/j.ultrasmedbio.2021.03.033
Source DB: PubMed Journal: Ultrasound Med Biol ISSN： 0301-5629 Impact factor: 3.694