Hanna Danielewicz1, Anna Dębińska2, Grzegorz Myszczyszyn3, Anna Myszkal4, Lidia Hirnle3, Anna Drabik-Chamerska2, Danuta Kalita2, Andrzej Boznański2. 1. 1st Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical University, ul. Chalubinskiego 2a, 50-368, Wroclaw, Poland. hanna.danielewicz@umed.wroc.pl. 2. 1st Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical University, ul. Chalubinskiego 2a, 50-368, Wroclaw, Poland. 3. 1st Department of Gynecology and Obstetrics, Wroclaw Medical University, ul. Chalubinskiego 5, 50-368, Wroclaw, Poland. 4. 1st Department of Gynecology and Obstetrics, University Hospital of Jan Mikulicz-Radecki in Wroclaw, ul. Chalubinskiego 5, 50-368, Wroclaw, Poland.
Abstract
BACKGROUND: Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Allergic diseases in pregnancy are mainly pre-existing but could also occur de novo. The immunological changes while pregnant, with increased Th2 lymphocyte activity, can facilitate allergen sensitisation. OBJECTIVE: The aim of this study was to evaluate the pattern of specific IgE (sIgE) sensitisation to common inhalant and food allergens in pregnancy, and assess its relationship to self-reported allergic disease. METHODS: We assessed 200 pregnant women, aged 20-38 years (mean age = 29 years), participant of ELMA (Epigenetic Hallmark of Maternal Atopy and Diet) study, living in a metropolitan area, with no pregnancy associated metabolic complications, for total IgE and allergen specific IgE to 20 allergens. RESULTS: 48% of pregnant women were sensitised to at least one allergen, at a cut-off point of 0.35 kU/L and they were assigned as atopic. However 42% in atopic group were not reporting any allergic disease. The most common inhalant allergens were: pollen (24.5%) and animal dander (23.5%). The most common food allergens were: cow's milk (5.5%) and apples (4.5%). 7.5% of women reported asthma, 21.5% allergic rhinitis, 11.5% atopic dermatitis and 18.5% food allergy. 8.5% of were taking medication for asthma or allergies. Atopic dermatitis had the highest tendency to become more severe during pregnancy. Total IgE values were significantly higher in atopic women. CONCLUSIONS: Allergic sensitisation is a common phenomenon in pregnancy. Some sensitisations could be asymptomatic. Further studies should investigate if sensitisation in mothers confers risks for immune alterations in their children.
BACKGROUND: Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Allergic diseases in pregnancy are mainly pre-existing but could also occur de novo. The immunological changes while pregnant, with increased Th2 lymphocyte activity, can facilitate allergen sensitisation. OBJECTIVE: The aim of this study was to evaluate the pattern of specific IgE (sIgE) sensitisation to common inhalant and food allergens in pregnancy, and assess its relationship to self-reported allergic disease. METHODS: We assessed 200 pregnant women, aged 20-38 years (mean age = 29 years), participant of ELMA (Epigenetic Hallmark of Maternal Atopy and Diet) study, living in a metropolitan area, with no pregnancy associated metabolic complications, for total IgE and allergen specific IgE to 20 allergens. RESULTS: 48% of pregnant women were sensitised to at least one allergen, at a cut-off point of 0.35 kU/L and they were assigned as atopic. However 42% in atopic group were not reporting any allergic disease. The most common inhalant allergens were: pollen (24.5%) and animal dander (23.5%). The most common food allergens were: cow's milk (5.5%) and apples (4.5%). 7.5% of women reported asthma, 21.5% allergic rhinitis, 11.5% atopic dermatitis and 18.5% food allergy. 8.5% of were taking medication for asthma or allergies. Atopic dermatitis had the highest tendency to become more severe during pregnancy. Total IgE values were significantly higher in atopic women. CONCLUSIONS:Allergic sensitisation is a common phenomenon in pregnancy. Some sensitisations could be asymptomatic. Further studies should investigate if sensitisation in mothers confers risks for immune alterations in their children.
Authors: Martina Sandberg; Anne Frykman; Yvonne Jonsson; Marie Persson; Jan Ernerudh; Göran Berg; Leif Matthiesen; Christina Ekerfelt; Maria C Jenmalm Journal: J Reprod Immunol Date: 2009-06-17 Impact factor: 4.054
Authors: Jean Francois Lauzon-Joset; Kyle T Mincham; Ana P Abad; Braden P Short; Patrick G Holt; Deborah H Strickland; Jonatan Leffler Journal: Clin Exp Allergy Date: 2019-12-14 Impact factor: 5.018
Authors: Hanna Danielewicz; Artur Gurgul; Anna Dębińska; Grzegorz Myszczyszyn; Tomasz Szmatoła; Anna Myszkal; Igor Jasielczuk; Anna Drabik-Chamerska; Lidia Hirnle; Andrzej Boznański Journal: Epigenetics Date: 2020-09-09 Impact factor: 4.528