Literature DB >> 3397060

The complete nucleotide sequence of murine beta-glucuronidase mRNA and its deduced polypeptide.

P M Gallagher1, M A D'Amore, S D Lund, R E Ganschow.   

Abstract

The complete nucleotide sequence of murine beta-glucuronidase (GUS) mRNA has been compiled from three overlapping cloned cDNAs and a single GUS-specific genomic clone. The sequence is composed of 2455 nucleotides, exclusive of the poly(A) tail. The 5' and 3' untranslated regions contain 12 and 499 bases, respectively, with the open reading frame encoding a polypeptide of 648 amino acids (74.2 kDa), including a 22 amino acid signal sequence. The nucleotide and deduced amino acid sequences of murine GUS are compared to those published for rat and human GUS and the results are presented. Murine GUS also shares amino acid sequence identity with Escherichia coli GUS and beta-galactosidase. The complete sequences of murine GUS mRNA and its deduced polypeptide provide a basis from which to study the mechanisms responsible for the well-characterized variation in GUS expression among inbred mouse strains.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3397060     DOI： 10.1016/0888-7543(88)90005-5

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  6 in total

1.  Differential expression of B1-containing transcripts in Leishmania-exposed macrophages.

Authors:  Y Ueda; G Chaudhuri
Journal:  J Biol Chem       Date:  2000-06-23       Impact factor: 5.157

2.  Restoration of normal lysosomal function in mucopolysaccharidosis type VII cells by retroviral vector-mediated gene transfer.

Authors:  J H Wolfe; E H Schuchman; L E Stramm; E A Concaugh; M E Haskins; G D Aguirre; D F Patterson; R J Desnick; E Gilboa
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

3.  Mucopolysaccharidosis type VII: characterization of mutations and molecular heterogeneity.

Authors:  S Tomatsu; S Fukuda; K Sukegawa; Y Ikedo; S Yamada; Y Yamada; T Sasaki; H Okamoto; T Kuwahara; S Yamaguchi
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

4.  Mapping of recombinant retrovirus integration sites that cause expression of the viral genome in murine embryonal carcinoma cells.

Authors:  M Taketo; T A Howard; M F Seldin
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

5.  DNA determinants of structural and regulatory variation within the murine beta-glucuronidase gene complex.

Authors:  C J Wawrzyniak; P M Gallagher; M A D'Amore; J E Carter; S D Lund; E M Rinchik; R E Ganschow
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

6.  Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes.

Authors:  R Bassel-Duby; M D Hernandez; Q Yang; J M Rochelle; M F Seldin; R S Williams
Journal:  Mol Cell Biol       Date:  1994-07       Impact factor: 4.272
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.