Mengying Han1, Dachuan Zhang1, Shaozhen Ding1, Yu Tian2, Xingxiang Cheng1, Le Yuan3, Dandan Sun1, Dongliang Liu1, Linlin Gong1, Cancan Jia1, Pengli Cai1,4, Weizhong Tu5, Junni Chen5, Qian-Nan Hu1. 1. CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China. 2. School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, Hubei, 430023, China. 3. Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. 4. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China. 5. Wuhan LifeSynther Science and Technology Co. Limited, Wuhan 430000, China.
Abstract
SUMMARY: The field of synthetic biology lacks a comprehensive knowledgebase for selecting synthetic target molecules according to their functions, economic applications, and known biosynthetic pathways. We implemented ChemHub, a knowledgebase containing >90,000 chemicals and their functions, along with related biosynthesis information for these chemicals that was manually extracted from >600,000 published studies by more than 100 people over the past 10 years. AVAILABILITY AND IMPLEMENTATION: Multiple algorithms were implemented to enable biosynthetic pathway design and precursor discovery, which can support investigation of the biosynthetic potential of these functional chemicals. ChemHub is freely available at: http://www.rxnfinder.org/chemhub/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
SUMMARY: The field of synthetic biology lacks a comprehensive knowledgebase for selecting synthetic target molecules according to their functions, economic applications, and known biosynthetic pathways. We implemented ChemHub, a knowledgebase containing >90,000 chemicals and their functions, along with related biosynthesis information for these chemicals that was manually extracted from >600,000 published studies by more than 100 people over the past 10 years. AVAILABILITY AND IMPLEMENTATION: Multiple algorithms were implemented to enable biosynthetic pathway design and precursor discovery, which can support investigation of the biosynthetic potential of these functional chemicals. ChemHub is freely available at: http://www.rxnfinder.org/chemhub/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.