Jing Ge1, Yiwen Chen1, Hui Yang2, Jingxue Zhao1, Dongyan Ren1, Xiaomei Wu1. 1. Department of Gynecology, The First People's Hospital of Yunnan Province and Affiliated Hospital of Kunming University of Science and Technology, Kunming, China. 2. Department of Pathology, The First People's Hospital of Yunnan Province and Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Abstract
BACKGROUND: Our study aims to analyze the expression and significance of estrogen receptor (ER) and progesterone receptor (PR) in endometrial tissues of patients with intrauterine adhesion (IUA). METHODS: Fifty-four patients with IUAs examined in our hospital from January 2017 to January 2019 were selected as the research object (observation group), 54 healthy women who had physical examinations during the same period were selected as the control group, and the immunohistochemical EnVision was used. Two-step and real-time fluorescent quantitative PCR methods were used to detect the expression levels of ER and PR in the endometrial tissues of the two groups of subjects. RESULTS: The immunohistochemical test results showed that ER's expression level in the observation group was significantly higher than that in the control group, and the difference between the two groups was statistically significant (P<0.05). The difference in PR expression levels between the two groups was insignificant (P<0.05). Real-time fluorescent quantitative PCR results showed ER and PR's expression levels in the observation group were significantly higher than those in the control group, and the difference between the two groups was statistically significant (P<0.05). CONCLUSIONS: After IUA can detect ER and PR expression, we can formulate a personalized hormone treatment plan to improve the clinical treatment effect. 2021 Gland Surgery. All rights reserved.
BACKGROUND: Our study aims to analyze the expression and significance of estrogen receptor (ER) and progesterone receptor (PR) in endometrial tissues of patients with intrauterine adhesion (IUA). METHODS: Fifty-four patients with IUAs examined in our hospital from January 2017 to January 2019 were selected as the research object (observation group), 54 healthy women who had physical examinations during the same period were selected as the control group, and the immunohistochemical EnVision was used. Two-step and real-time fluorescent quantitative PCR methods were used to detect the expression levels of ER and PR in the endometrial tissues of the two groups of subjects. RESULTS: The immunohistochemical test results showed that ER's expression level in the observation group was significantly higher than that in the control group, and the difference between the two groups was statistically significant (P<0.05). The difference in PR expression levels between the two groups was insignificant (P<0.05). Real-time fluorescent quantitative PCR results showed ER and PR's expression levels in the observation group were significantly higher than those in the control group, and the difference between the two groups was statistically significant (P<0.05). CONCLUSIONS: After IUA can detect ER and PR expression, we can formulate a personalized hormone treatment plan to improve the clinical treatment effect. 2021 Gland Surgery. All rights reserved.
Authors: L Cody Smith; Santiago Moreno; Sarah Robinson; Marlene Orandle; Dale W Porter; Dipesh Das; Navid B Saleh; Tara Sabo-Attwood Journal: NanoImpact Date: 2019-03-21
Authors: Mae Wu Healy; Brian Schexnayder; Matthew T Connell; Nancy Terry; Alan H DeCherney; John M Csokmay; Belinda J Yauger; Micah J Hill Journal: Am J Obstet Gynecol Date: 2016-05-10 Impact factor: 8.661