BACKGROUND: To explore the expression level of coagulation and fibrinolysis-related indexes in the plasma of breast cancer patients after surgery, and explore their predictive value for deep venous thrombosis (DVT). METHODS: From May 2016 to May 2019, 63 patients with lower extremity DVT after radical mastectomy in our hospital were selected as the thrombus group, and 69 patients without venous thrombosis after radical mastectomy were selected as the control group. The levels of D-dimer (D-D) and fibrinolytic product (FDP) were measured by latex enhanced immunoturbidimetry, Fibrinogen (FIB) levels were measured using the von Clauss method, thrombin antithrombin complex (TAT) and thrombomodulin (TM) levels were measured by enzyme-linked immunosorbent assay (ELISA), and the evaluation value of coagulation markers on tumor thrombosis was analyzed by receiver operating characteristic curve (ROC) curve analysis. RESULTS: There were significant differences in blood pressure, platelet count (PLT) level, diabetes history, and tumor metastasis between the two groups (P<0.05). The levels of PT, D-D, FDP, TAT, and TM in the thrombus group were significantly higher than those in control group (P<0.05). The area under the curve (AUC) of D-D, FDP, and TAT were 0.790, 0.881, and 0.672, respectively and there was a marked difference among the indexes (P<0.05). The AUC of FDP was the largest, and the sensitivity and diagnostic value of FDP were the highest. CONCLUSIONS: The plasma levels of FDP, D-D, TAT, and TM in breast cancer patients with DVT after radical mastectomy were significantly increased, which is related to imbalanced coagulation and fibrinolysis functioning in patients. FDP had the highest predictive value for DVT after radical mastectomy. 2021 Gland Surgery. All rights reserved.
BACKGROUND: To explore the expression level of coagulation and fibrinolysis-related indexes in the plasma of breast cancer patients after surgery, and explore their predictive value for deep venous thrombosis (DVT). METHODS: From May 2016 to May 2019, 63 patients with lower extremity DVT after radical mastectomy in our hospital were selected as the thrombus group, and 69 patients without venous thrombosis after radical mastectomy were selected as the control group. The levels of D-dimer (D-D) and fibrinolytic product (FDP) were measured by latex enhanced immunoturbidimetry, Fibrinogen (FIB) levels were measured using the von Clauss method, thrombin antithrombin complex (TAT) and thrombomodulin (TM) levels were measured by enzyme-linked immunosorbent assay (ELISA), and the evaluation value of coagulation markers on tumor thrombosis was analyzed by receiver operating characteristic curve (ROC) curve analysis. RESULTS: There were significant differences in blood pressure, platelet count (PLT) level, diabetes history, and tumor metastasis between the two groups (P<0.05). The levels of PT, D-D, FDP, TAT, and TM in the thrombus group were significantly higher than those in control group (P<0.05). The area under the curve (AUC) of D-D, FDP, and TAT were 0.790, 0.881, and 0.672, respectively and there was a marked difference among the indexes (P<0.05). The AUC of FDP was the largest, and the sensitivity and diagnostic value of FDP were the highest. CONCLUSIONS: The plasma levels of FDP, D-D, TAT, and TM in breast cancer patients with DVT after radical mastectomy were significantly increased, which is related to imbalanced coagulation and fibrinolysis functioning in patients. FDP had the highest predictive value for DVT after radical mastectomy. 2021 Gland Surgery. All rights reserved.
Entities:
Keywords:
Coagulation function index; breast cancer; deep venous thrombosis (DVT); fibrinolysis function index; postoperative
Authors: Li Zou; Feng-Hua Liu; Pei-Pei Shen; Yan Hu; Xiao-Qian Liu; Ying-Ying Xu; Qi-Liang Pen; Bei Wang; Ya-Qun Zhu; Ye Tian Journal: Breast Cancer Date: 2018-02-03 Impact factor: 4.239
Authors: Mirela Tuzovic; Joerg Herrmann; Cezar Iliescu; Kostas Marmagkiolis; Boback Ziaeian; Eric H Yang Journal: Curr Treat Options Cardiovasc Med Date: 2018-04-07
Authors: Joy Ogbechi; Marie-Thérèse Ruf; Belinda S Hall; Katherine Bodman-Smith; Moritz Vogel; Hua-Lin Wu; Alexander Stainer; Charles T Esmon; Josefin Ahnström; Gerd Pluschke; Rachel E Simmonds Journal: PLoS Pathog Date: 2015-07-16 Impact factor: 6.823