Zeyu Zhang1, Fada Xia1, Wenlong Wang1, Yun Huang2, Xinying Li1. 1. Department of Thyroid Surgery, Xiangya Hospital, Central South University, Changsha, China. 2. Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.
Abstract
BACKGROUND: A high proportion of papillary thyroid carcinoma (PTC) patients are involved in central lymph node metastasis (CLNM) with preoperative imaging examinations showing clinically nodal-negative (cN0). Meanwhile, many inflammatory biomarkers are also proven as effective factors to predict the outcomes of cancer patients and tumor progression. Thus, the values of these factors are investigated to help detecting CLNM in cN0 PTC patients. METHODS: 406 cN0 PTC patients who underwent curative surgery were retrospectively analyzed. CLNM was determined by histopathological examination following the thyroidectomy. Multiple inflammatory biomarkers were comprehensively researched. RESULTS: A total of 406 consecutive patients were eventually included. The univariate and multivariate analyses revealed that age (OR: 0.924, 95% CI: 0.909, 0.940), gender (OR: 1.781, 95% CI: 1.060, 2.993), location of tumors (OR: 2.229, 95% CI: 1.228, 4.046) and level of systemic immune-inflammation index (SII) (OR: 1.005, 95% CI: 1.004, 1.006) were independently associated with CLNM in cN0 PTC patients, and the SII-based predictive model was constructed using these four factors. Receiver operating characteristic (ROC) curves showed significant results of the SII-based predictive model in PTC cohort with area under curve (AUC) as 0.814 (95% CI: 0.771-0.857) and in PTMC subgroup with AUC as 0.803 (95% CI: 0.752-0.854). CONCLUSIONS: The SII-based model can effectively help predicting CLNM in both cN0 PTC patients and cN0 PTMC patients. 2021 Gland Surgery. All rights reserved.
BACKGROUND: A high proportion of papillary thyroid carcinoma (PTC) patients are involved in central lymph node metastasis (CLNM) with preoperative imaging examinations showing clinically nodal-negative (cN0). Meanwhile, many inflammatory biomarkers are also proven as effective factors to predict the outcomes of cancer patients and tumor progression. Thus, the values of these factors are investigated to help detecting CLNM in cN0 PTC patients. METHODS: 406 cN0 PTC patients who underwent curative surgery were retrospectively analyzed. CLNM was determined by histopathological examination following the thyroidectomy. Multiple inflammatory biomarkers were comprehensively researched. RESULTS: A total of 406 consecutive patients were eventually included. The univariate and multivariate analyses revealed that age (OR: 0.924, 95% CI: 0.909, 0.940), gender (OR: 1.781, 95% CI: 1.060, 2.993), location of tumors (OR: 2.229, 95% CI: 1.228, 4.046) and level of systemic immune-inflammation index (SII) (OR: 1.005, 95% CI: 1.004, 1.006) were independently associated with CLNM in cN0 PTC patients, and the SII-based predictive model was constructed using these four factors. Receiver operating characteristic (ROC) curves showed significant results of the SII-based predictive model in PTC cohort with area under curve (AUC) as 0.814 (95% CI: 0.771-0.857) and in PTMC subgroup with AUC as 0.803 (95% CI: 0.752-0.854). CONCLUSIONS: The SII-based model can effectively help predicting CLNM in both cN0 PTC patients and cN0 PTMC patients. 2021 Gland Surgery. All rights reserved.
Entities:
Keywords:
Papillary thyroid carcinoma (PTC); central lymph node metastasis (CLNM); inflammatory biomarker; systemic immune-inflammation index (SII)
Authors: Alessandro Russo; Marco Russano; Antonio Russo; Tindara Franchina; Maria R Migliorino; Giuseppe Aprile; Giovanni Mansueto; Alfredo Berruti; Alfredo Falcone; Michele Aieta; Alain Gelibter; Sandro Barni; Michele Maio; Olga Martelli; Francesco Pantano; Daniela Iacono; Lorenzo Calvetti; Silvia Quadrini; Elisa Roca; Enrico Vasile; Marco Imperatori; Mario Occhipinti; Antonio Galvano; Fausto Petrelli; Luana Calabrò; Giulia Pasquini; Salvatore Intagliata; Giuseppina R R Ricciardi; Giuseppe Tonini; Daniele Santini; Vincenzo Adamo Journal: Adv Ther Date: 2020-01-30 Impact factor: 3.845