Dhruv Nayyar1,2, Tuan Nguyen1,3, Faraz Pathan4,5, Giau Vo1, David Richards6, Liza Thomas3,6,7, Hany Dimitri1,3, James Otton1,3. 1. Cardiology Department, Liverpool Hospital, Sydney, NSW, Australia. 2. School of Medicine, Western Sydney University, Sydney, NSW, Australia. 3. South West Clinical School, University of New South Wales, Sydney, NSW, Australia. 4. Cardiology Department, Nepean Hospital, Sydney, NSW, Australia. 5. Charles Perkins Centre Sydney, Nepean Clinical School, University of Sydney, Sydney, NSW, Australia. 6. Westmead Clinical School, University of Sydney, Sydney, NSW, Australia. 7. Cardiology Department, Westmead Hospital, Sydney, NSW, Australia.
Abstract
BACKGROUND: The prognostic value of cardiac magnetic resonance (CMR) derived left atrial (LA) strain, ejection fraction (LAEF) and indexed volumes (LAVImax and LAVImin) after ST-elevation myocardial infarction (STEMI) remains controversial. The aim of this study was to assess the relationship between LA function and major adverse cardiovascular events (MACE) after STEMI. METHODS: A total of 202 prospectively recruited patients who underwent CMR at median day 4 after STEMI had complete CMR data for feature tracking assessment. LA reservoir and booster strain were quantified based on the average of three independently repeated measurements. RESULTS: MACE occurred in 35 patients during a median follow up of 607 days. Patients with MACE had lower median LA reservoir strain (18.9% vs. 29.4%, P<0.001), LA booster strain (9.4% vs. 13.0%, P=0.002) and LAEF (41.5% vs. 49.2%, P<0.001) than patients without MACE. Kaplan-Meier analyses demonstrated a difference in MACE between high- and low-risk groups for LA reservoir strain (cutoff 19.2%, P<0.001), LA booster strain (cutoff 9.7%, P<0.001) and LAEF (cutoff 38.5%, P<0.001). The AUC increased from 0.713 (95% CI: 0.608-0.818) for LVEF to 0.775 (95% CI: 0.680-0.870) when LA reservoir strain was added to LVEF (P=0.047). Univariate Cox regression analysis showed that all LA parameters had a significant effect on MACE, while multivariate analysis found LA reservoir strain was an independent predictor of MACE (HR 0.905; 95% CI: 0.843-0.972, P=0.006). CONCLUSIONS: CMR derived LA reservoir strain independently predicted MACE after STEMI when adjusted for standard risk measures. 2021 Cardiovascular Diagnosis and Therapy. All rights reserved.
BACKGROUND: The prognostic value of cardiac magnetic resonance (CMR) derived left atrial (LA) strain, ejection fraction (LAEF) and indexed volumes (LAVImax and LAVImin) after ST-elevation myocardial infarction (STEMI) remains controversial. The aim of this study was to assess the relationship between LA function and major adverse cardiovascular events (MACE) after STEMI. METHODS: A total of 202 prospectively recruited patients who underwent CMR at median day 4 after STEMI had complete CMR data for feature tracking assessment. LA reservoir and booster strain were quantified based on the average of three independently repeated measurements. RESULTS: MACE occurred in 35 patients during a median follow up of 607 days. Patients with MACE had lower median LA reservoir strain (18.9% vs. 29.4%, P<0.001), LA booster strain (9.4% vs. 13.0%, P=0.002) and LAEF (41.5% vs. 49.2%, P<0.001) than patients without MACE. Kaplan-Meier analyses demonstrated a difference in MACE between high- and low-risk groups for LA reservoir strain (cutoff 19.2%, P<0.001), LA booster strain (cutoff 9.7%, P<0.001) and LAEF (cutoff 38.5%, P<0.001). The AUC increased from 0.713 (95% CI: 0.608-0.818) for LVEF to 0.775 (95% CI: 0.680-0.870) when LA reservoir strain was added to LVEF (P=0.047). Univariate Cox regression analysis showed that all LA parameters had a significant effect on MACE, while multivariate analysis found LA reservoir strain was an independent predictor of MACE (HR 0.905; 95% CI: 0.843-0.972, P=0.006). CONCLUSIONS: CMR derived LA reservoir strain independently predicted MACE after STEMI when adjusted for standard risk measures. 2021 Cardiovascular Diagnosis and Therapy. All rights reserved.
Entities:
Keywords:
Left atrial function; ST-elevation myocardial infarction (STEMI); cardiac magnetic resonance (CMR); left atrial strain; prognosis
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