Devin J Burke1, Sarah G Mahonski1, Anne C Van Cott1. 1. Department of Neurology (DJB, ACVC), University of Pittsburgh Medical Center; Department of Emergency Medicine (SGM), Heritage Valley Health System; and Veteran Affairs Pittsburgh Health System (ACVC), PA.
Abstract
PURPOSE OF REVIEW: Kratom (mitragynine) is a commercially available herbal supplement that is gaining popularity in the United States. Kratom is associated with a variety of neurologic effects. This review will discuss kratom's association with seizure through 3 cases and highlight what neurologists should know about kratom's clinical effects and legal status. RECENT FINDINGS: Kratom is currently commercially available, unscheduled by the US Drug Enforcement Administration, and a topic of regulatory debate in the United States. Large poison center reviews have suggested that kratom use is associated with seizure. There have been limited case studies to corroborate this finding. We present 3 cases in which seizures were associated with kratom use in patients treated for epilepsy. SUMMARY: Since 2008, kratom use is rising in prevalence in the United States aided by lack of regulation. Neurologists need to be aware of its association with seizure and other neurologic side effects.
PURPOSE OF REVIEW: Kratom (mitragynine) is a commercially available herbal supplement that is gaining popularity in the United States. Kratom is associated with a variety of neurologic effects. This review will discuss kratom's association with seizure through 3 cases and highlight what neurologists should know about kratom's clinical effects and legal status. RECENT FINDINGS: Kratom is currently commercially available, unscheduled by the US Drug Enforcement Administration, and a topic of regulatory debate in the United States. Large poison center reviews have suggested that kratom use is associated with seizure. There have been limited case studies to corroborate this finding. We present 3 cases in which seizures were associated with kratom use in patients treated for epilepsy. SUMMARY: Since 2008, kratom use is rising in prevalence in the United States aided by lack of regulation. Neurologists need to be aware of its association with seizure and other neurologic side effects.
Authors: András Váradi; Gina F Marrone; Travis C Palmer; Ankita Narayan; Márton R Szabó; Valerie Le Rouzic; Steven G Grinnell; Joan J Subrath; Evelyn Warner; Sanjay Kalra; Amanda Hunkele; Jeremy Pagirsky; Shainnel O Eans; Jessica M Medina; Jin Xu; Ying-Xian Pan; Attila Borics; Gavril W Pasternak; Jay P McLaughlin; Susruta Majumdar Journal: J Med Chem Date: 2016-09-02 Impact factor: 7.446
Authors: Ken Gershman; Krista Timm; Meredith Frank; Laurissa Lampi; Jonathan Melamed; Roy Gerona; Andrew A Monte Journal: N Engl J Med Date: 2019-01-03 Impact factor: 91.245
Authors: Walter C Prozialeck; Bonnie A Avery; Edward W Boyer; Oliver Grundmann; Jack E Henningfield; Andrew C Kruegel; Lance R McMahon; Christopher R McCurdy; Marc T Swogger; Charles A Veltri; Darshan Singh Journal: Int J Drug Policy Date: 2019-05-16
Authors: Samantha Hughes; David van de Klashorst; Charles A Veltri; Oliver Grundmann Journal: Int J Environ Res Public Health Date: 2022-05-22 Impact factor: 4.614