Literature DB >> 33966939

Detecting and Rescuing Stalled Ribosomes.

Matthew C J Yip1, Sichen Shao2.   

Abstract

Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that rescue stalled ribosomes must selectively detect rare aberrant translational complexes and process the heterogeneous components. Ribosome-associated quality control pathways eliminate problematic messenger RNAs and nascent proteins on stalled translational complexes. In addition, recent studies have uncovered general principles of stall recognition upstream of quality control pathways and fail-safe mechanisms that ensure nascent proteome integrity. Here, we discuss developments in our mechanistic understanding of the detection and rescue of stalled ribosomal complexes in eukaryotes.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ribosome collisions; ribosome stalling; ribosome-associated quality control (RQC)

Mesh：

Substances：

Year:  2021        PMID： 33966939      PMCID： PMC8487456          DOI： 10.1016/j.tibs.2021.03.008

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   14.264


  101 in total

1.  Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.

Authors:  Quentin Defenouillère; Elodie Zhang; Abdelkader Namane; John Mouaikel; Alain Jacquier; Micheline Fromont-Racine
Journal:  J Biol Chem       Date:  2016-04-18       Impact factor: 5.157

2.  A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay.

Authors:  Sarah E Cole; Frederick J LaRiviere; Christopher N Merrikh; Melissa J Moore
Journal:  Mol Cell       Date:  2009-05-14       Impact factor: 17.970

3.  A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.

Authors:  Jessie Chu; Nancy A Hong; Claudio A Masuda; Brian V Jenkins; Keats A Nelms; Christopher C Goodnow; Richard J Glynne; Hua Wu; Eliezer Masliah; Claudio A P Joazeiro; Steve A Kay
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-05       Impact factor: 11.205

4.  GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.

Authors:  Kelsey L Hickey; Kimberley Dickson; J Zachery Cogan; Joseph M Replogle; Michael Schoof; Karole N D'Orazio; Niladri K Sinha; Jeffrey A Hussmann; Marco Jost; Adam Frost; Rachel Green; Jonathan S Weissman; Kamena K Kostova
Journal:  Mol Cell       Date:  2020-07-28       Impact factor: 17.970

5.  ASC1 and RPS3: new actors in 18S nonfunctional rRNA decay.

Authors:  Kelly A Limoncelli; Christopher N Merrikh; Melissa J Moore
Journal:  RNA       Date:  2017-09-27       Impact factor: 4.942

6.  Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation.

Authors:  Cole S Sitron; Joseph H Park; Onn Brandman
Journal:  RNA       Date:  2017-02-21       Impact factor: 4.942

7.  Oxidation and alkylation stresses activate ribosome-quality control.

Authors:  Liewei L Yan; Carrie L Simms; Fionn McLoughlin; Richard D Vierstra; Hani S Zaher
Journal:  Nat Commun       Date:  2019-12-09       Impact factor: 14.919

8.  EDF1 coordinates cellular responses to ribosome collisions.

Authors:  Niladri K Sinha; Alban Ordureau; Katharina Best; James A Saba; Boris Zinshteyn; Elayanambi Sundaramoorthy; Amit Fulzele; Danielle M Garshott; Timo Denk; Matthias Thoms; Joao A Paulo; J Wade Harper; Eric J Bennett; Roland Beckmann; Rachel Green
Journal:  Elife       Date:  2020-08-03       Impact factor: 8.140

9.  Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.

Authors:  Rati Verma; Robert S Oania; Natalie J Kolawa; Raymond J Deshaies
Journal:  Elife       Date:  2013-01-22       Impact factor: 8.140

10.  Pre-emptive Quality Control of a Misfolded Membrane Protein by Ribosome-Driven Effects.

Authors:  Ramya Lakshminarayan; Ben P Phillips; Imogen L Binnian; Natalia Gomez-Navarro; Norberto Escudero-Urquijo; Alan J Warren; Elizabeth A Miller
Journal:  Curr Biol       Date:  2020-01-16       Impact factor: 10.834
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  7 in total

Review 1.  The mechanisms of integral membrane protein biogenesis.

Authors:  Ramanujan S Hegde; Robert J Keenan
Journal:  Nat Rev Mol Cell Biol       Date:  2021-09-23       Impact factor: 94.444

2.  iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.

Authors:  Danielle M Garshott; Heeseon An; Elayanambi Sundaramoorthy; Marilyn Leonard; Alison Vicary; J Wade Harper; Eric J Bennett
Journal:  Cell Rep       Date:  2021-08-31       Impact factor: 9.423

Review 3.  Ribosome-associated quality-control mechanisms from bacteria to humans.

Authors:  Sebastian Filbeck; Federico Cerullo; Stefan Pfeffer; Claudio A P Joazeiro
Journal:  Mol Cell       Date:  2022-04-21       Impact factor: 19.328

Review 4.  Canary in a coal mine: collided ribosomes as sensors of cellular conditions.

Authors:  Kyusik Q Kim; Hani S Zaher
Journal:  Trends Biochem Sci       Date:  2021-10-02       Impact factor: 14.264

5.  Net Charges of the Ribosomal Proteins of the S10 and spc Clusters of Halophiles Are Inversely Related to the Degree of Halotolerance.

Authors:  Madhan R Tirumalai; Daniela Anane-Bediakoh; Sidharth Rajesh; George E Fox
Journal:  Microbiol Spectr       Date:  2021-12-15

Review 6.  The trinity of ribosome-associated quality control and stress signaling for proteostasis and neuronal physiology.

Authors:  Jumin Park; Jongmin Park; Jongbin Lee; Chunghun Lim
Journal:  BMB Rep       Date:  2021-09       Impact factor: 4.778

7.  ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.

Authors:  Kristian Lied Wollen; Lars Hagen; Cathrine B Vågbø; Renana Rabe; Tobias S Iveland; Per Arne Aas; Animesh Sharma; Bjørnar Sporsheim; Hilde O Erlandsen; Vuk Palibrk; Magnar Bjørås; Davi M Fonseca; Nima Mosammaparast; Geir Slupphaug
Journal:  J Transl Med       Date:  2021-07-03       Impact factor: 5.531
  7 in total

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